Intake of vitamins D and A and calcium and risk of non-Hodgkin lymphoma: San Francisco Bay Area population-based case-control study.
Intake of vitamins D and A and calcium and risk of non-Hodgkin lymphoma: San Francisco Bay Area population-based case-control study.
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DOI：
10.1080/01635581.2012.689916
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Gong Z
中科院分区：
文献类型：
--
作者：
Mikhak B;Bracci PM;Gong Z
几种被认为具有潜在癌症保护作用的营养素与非霍奇金淋巴瘤 (NHL) 风险的相关性不一致。在旧金山湾区基于人口的病例对照中，通过对 4,133 名参与者（2052 名病例，2081 名对照）进行面对面访谈，使用半定量食物频率问卷收集饮食史数据，包括维生素补充剂的使用情况。数据用于确定维生素 D、A 和钙的摄入水平与 NHL 和 NHL 亚型风险的关联。使用调整后的无条件逻辑回归计算优势比 (OR) 和 95% 置信区间 (CI) 作为相对风险的估计。增加食物和补充剂中维生素 D 的摄入量与男性 NHL 风险呈正相关（第五个五分位数：OR=1.6，95% CI= 1.0-2.4，Ptrend=0.07），与女性和男性的弥漫性大 B 细胞淋巴瘤 (DLBCL) 呈正相关（第五个五分位数：OR=1.6，95% CI=1.0-2.5，Ptrend=0.02），这主要是由于对男性的影响（Ptrend=0.03）。这些结果并不支持维生素 D 摄入量与 NHL 风险之间存在强有力的作用，但与男性 DLBCL 风险之间存在潜在关联。我们的结果应该保守地解释，直到可以进行更大规模的汇总研究的进一步调查，以更好地评估维生素 D 摄入在淋巴瘤发生中的作用。
Several nutrients identified as potentially cancer protective have been inconsistently associated with non-Hodgkin lymphoma (NHL) risk. Dietary history data, including use of vitamin supplements, were collected using a semi-quantitative food frequency questionnaire administered during in-person interviews with 4,133 participants (2052 cases, 2081 controls) in a San Francisco Bay Area population-based case-control. Data were used to determine the association of intake levels of vitamins D, A and calcium with risk of NHL and NHL subtypes. Odds ratios (OR) and 95% confidence intervals (CI) were computed as estimates of relative risk using adjusted unconditional logistic regression. Increasing vitamin D intake from food and supplements was positively associated with NHL risk in men (5th quintile: OR=1.6, 95% CI= 1.0-2.4, Ptrend=0.07) and with diffuse large B-cell lymphoma (DLBCL) in women and men (5th quintile: OR=1.6, 95% CI=1.0-2.5, Ptrend=0.02), that was largely due to the effect in men (Ptrend=0.03). These results do not support a strong role for vitamin D intake with NHL risk with the exception of a potential association for DLBCL risk in men. Our results should be interpreted conservatively until further investigation in larger pooled studies can be conducted to better assess the role of vitamin D intake in lymphomagenesis.
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