Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy.
Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy.
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DOI：
10.1016/j.schres.2012.08.022
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发表时间：
2012-11
影响因子：
4.5
通讯作者：
Byne W
中科院分区：
文献类型：
--
作者：
Hazlett EA;Collazo T;Zelmanova Y;Entis JJ;Chu KW;Goldstein KE;Roussos P;Haznedar MM;Koenigsberg HW;New AS;Buchsbaum MS;Hershowitz JP;Siever LJ;Byne W
Mounting evidence suggests that white matter abnormalities and altered subcortical–cortical connectivity may be central to the pathology of schizophrenia (SZ). The anterior limb of the internal capsule (ALIC) is an important thalamo-frontal white-matter tract shown to have volume reductions in SZ and to a lesser degree in schizotypal personality disorder (SPD). While fractional anisotropy (FA) and connectivity abnormalities in the ALIC have been reported in SZ, they have not been examined in SPD. In the current study, magnetic resonance (MRI) and diffusion tensor imaging (DTI) were obtained in age- and sex-matched individuals with SPD (n=33) and healthy controls (HCs; n=38). The ALIC was traced bilaterally on five equally spaced dorsal-to-ventral axial slices from each participant’s MRI scan and co-registered to DTI for the calculation of FA. Tractography was used to examine tracts between the ALIC and two key Brodmann areas (BAs; BA10, BA45) within the dorsolateral prefrontal cortex (DLPFC). Compared with HCs, the SPD participants exhibited (a) smaller relative volume at the mid-ventral ALIC slice level but not the other levels; (b) normal FA within the ALIC; (c) fewer relative number of tracts between the most-dorsal ALIC levels and BA10 but not BA45 and (d) fewer dorsal ALIC–DLPFC tracts were associated with greater symptom severity in SPD. In contrast to prior SZ studies that report lower FA, individuals with SPD show sparing. Our findings are consistent with a pattern of milder thalamo-frontal dysconnectivity in SPD than schizophrenia.
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影响因子：
6.7
作者：
Hazlett, Erin A.;Goldstein, Kim E.;Kolaitis, Jeanine C.
通讯作者：
Kolaitis, Jeanine C.
影响因子：
2.5
作者：
de Souza Duran, Fabio Luis;Hoexter, Marcelo Queiroz;Busatto, Geraldo Filho
通讯作者：
Busatto, Geraldo Filho
影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
2.5
作者：
GIGUERE, M;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
DOI：
10.1176/appi.neuropsych.18.3.364
发表时间：
2006-06-01
影响因子：
2.9
作者：
Brickman, Adam M.;Buchsbaum, Monte S.;Shihabuddin, Lina
通讯作者：
Shihabuddin, Lina