A review of structural MRI and diffusion tensor imaging in schizotypal personality disorder.
A review of structural MRI and diffusion tensor imaging in schizotypal personality disorder.
复制标题
DOI：
10.1007/s11920-011-0241-z
复制
发表时间：
2012-02
影响因子：
6.7
通讯作者：
Kolaitis, Jeanine C.
中科院分区：
文献类型：
--
作者：
Hazlett, Erin A.;Goldstein, Kim E.;Kolaitis, Jeanine C.
关键词：
Individuals with schizotypal personality disorder (SPD) share genetic, phenomenologic, and cognitive abnormalities with people diagnosed with schizophrenia. To date, 15 structural MRI studies of the brain have examined size, and 3 diffusion tensor imaging studies have examined white matter connectivity in SPD. Overall, both types of structural neuroimaging modalities have shown temporal lobe abnormalities similar to those observed in schizophrenia, while frontal lobe regions appear to show more sparing. This intriguing pattern suggests that frontal lobe sparing may suppress psychosis, which is consistent with the idea of a possible neuroprotective factor. In this paper, we review these 18 studies and discuss whether individuals with SPD who both resemble and differ from schizophrenia patients in their phenomenology, share some or all of the structural brain imaging characteristics of schizophrenia. We attempt to group the MRI abnormalities in SPD into three patterns: 1) a spectrum of severity—abnormalities are similar to those observed in schizophrenia but not so severe; 2) a spectrum of region—abnormalities affecting some, but not all, brain regions affected in schizophrenia; and 3) a spectrum of compensation—abnormalities reflecting greater-than-normal white matter volume, possibly serving as a buffer or compensatory mechanism protecting the individual with SPD from the frank psychosis observed in schizophrenia.
登录
查看更多内容
影响因子：
4.5
作者：
Fujiwara, Hironobu;Namiki, Chihiro;Murai, Toshiya
通讯作者：
Murai, Toshiya
影响因子：
17.7
作者：
Dickey, CC;McCarley, RW;Shenton, ME
通讯作者：
Shenton, ME
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
6.6
作者：
Bergman, AJ;Harvey, PD;Siever, LJ
通讯作者：
Siever, LJ
影响因子：
17.7
作者：
Dickey, CC;McCarley, RW;Shenton, ME
通讯作者：
Shenton, ME