Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.
Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.
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DOI：
10.1016/j.jmbbm.2015.01.018
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发表时间：
2015-05
影响因子：
3.9
通讯作者：
Luciano, Mark G.
中科院分区：
文献类型：
--
作者：
Yang, Jun;Charif, Andrea C.;Puskas, Judit E.;Phillips, Hannah;Shanahan, Kaitlyn J.;Garsed, Jessica;Fleischman, Aaron;Goldman, Ken;Luebbers, Matthew T.;Dombrowski, Stephen M.;Luciano, Mark G.
本研究调查了实验性热塑性橡胶Arbomatrix™的生物相容性，该橡胶将用作新型颅内压（ICP）传感器硅芯片上的保护涂层。Arbomatrix™通过植入持续时间为60天的大鼠模型，以生物相容性商业硅橡胶分流管为基准进行脑内测试。还植入了裸硅芯片。结果显示，脑-植入物边界和周围组织中的细胞分布相似。神经元和胶质细胞密度的定量分析未显示植入物之间的显著差异。通过组织学和免疫组织化学评价，我们得出结论，Arbomatrix™被大脑良好耐受。由于其优异的阻隔性能，Arbomatrix™已被证明是新型ICP监测芯片的优秀保护涂层。
This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix™ that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix™ was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix™ is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix™ has already been shown to be an excellent protective coating for new ICP monitoring chip.
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影响因子：
12.7
作者：
STENSAAS, SS;STENSAAS, LJ
通讯作者：
STENSAAS, LJ
影响因子：
3.3
作者：
ENG, LF
通讯作者：
ENG, LF
影响因子：
2.4
作者：
AMMAR, A
通讯作者：
AMMAR, A
影响因子：
4.1
作者：
DYMOND, AM;KAECHELE, LE;CRANDALL, PH
通讯作者：
CRANDALL, PH
影响因子：
4.2
作者：
WEST, MJ
通讯作者：
WEST, MJ