Anterior Paraventricular Thalamus to Nucleus Accumbens Projection Is Involved in Feeding Behavior in a Novel Environment.
Anterior Paraventricular Thalamus to Nucleus Accumbens Projection Is Involved in Feeding Behavior in a Novel Environment.
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前室旁丘脑到伏核的投射涉及新环境中的进食行为
DOI：
10.3389/fnmol.2018.00202
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发表时间：
2018
影响因子：
4.8
通讯作者：
Zhou YD
中科院分区：
文献类型：
--
作者：
Cheng J;Wang J;Ma X;Ullah R;Shen Y;Zhou YD
在一个新的环境中寻找食物是生存所必需的。动物协调复杂的动机状态，并决定是开始进食还是逃离陌生的场景。丘脑室旁核(PVT)中的神经元接受来自下丘脑、前脑和尾侧脑干的多个输入，这些输入被认为是调节摄食行为的。PVT神经元也投射到与奖励和动机有关的前脑区域。值得注意的是，当出现刺激刺激时，投射到伏隔核(NAC)的PVT神经元被激活。PVT-NAC通路的光遗传激活已被证明增加了在工具性任务中寻找蔗糖的动机。然而，PVT电路如何在新的环境中调节摄食行为仍然很不清楚。在本研究中，我们发现，投射到NAC的PVT前部(APVT)中的谷氨酸能神经元的活动决定了小鼠的新奇抑制摄食行为。APVT-NAC投影的光遗传激活增加了小鼠在适度食物限制下的进食时间和食物消耗，在一种新的开阔场地中，食物放置在中央区域。然而，aPVT-NAC的激活并没有改变探索性和焦虑性行为。我们的工作表明，在小鼠中激活aPVT-NAC通路会产生在新环境中消费食物的动机。
Foraging food in a novel environment is essential for survival. Animals coordinate the complex motivated states and decide whether to initiate feeding or escape from unfamiliar scenes. Neurons in the paraventricular thalamic nucleus (PVT) receive multiple inputs from the hypothalamus, forebrain, and caudal brainstem that are known to regulate feeding behavior. The PVT neurons also project to the forebrain regions that are involved in reward and motivation. Notably, the PVT neurons projecting to the nucleus accumbens (NAc) are activated when an incentive stimulus is presented. Optogenetic activation of the PVT-NAc path has been shown to increase the motivation for sucrose-seeking in instrumental tasks. However, how the PVT circuitry regulates the feeding behavior in a novel environment remains largely obscure. In the present study, we found that the activity of glutamatergic neurons in the anterior PVT (aPVT) projecting to the NAc dictates the novelty-suppressed feeding behavior in mice. Optogenetic activation of the aPVT-NAc projection increased the feeding time and food consumption in mice under a moderate food restriction in a novel open field where the food was placed in the central area. The exploratory and anxiety-like behaviors, however, were not altered by the aPVT-NAc activation. Our work reveals that activation of the aPVT-NAc pathway in mice generates a motivation to consume food in a novel environment.
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影响因子：
5.2
作者：
Cassidy RM;Tong Q
通讯作者：
Tong Q
影响因子：
2.9
作者：
Aznar, S;Qian, ZX;Knudsen, GM
通讯作者：
Knudsen, GM
影响因子：
56.9
作者：
HOEBEL, BG;TEITELBAUM, P
通讯作者：
TEITELBAUM, P
50 年来抗焦虑药物发现的障碍和希望。
DOI：
10.1038/nrd4075
发表时间：
2013-09
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
通讯作者：
--
影响因子：
3
作者：
Hsu DT;Kirouac GJ;Zubieta JK;Bhatnagar S
通讯作者：
Bhatnagar S