Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.
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4-硫尿苷生物合成过程中酶过硫化物和二硫化物中间体的直接证据。

DOI:
10.1039/b604040c
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发表时间:
2006
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Mueller,EugeneG
Mueller,EugeneG
中科院分区:
--
文献类型:
--
作者:
Wright,ChapmanM;Christman,GlennD;Snellinger,AnnM;Johnston,MurrayV;Mueller,EugeneG

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两种已提出的4-硫代尿苷生成机制共享关键的半胱氨酸过硫化物和二硫化物中间体,先前已报道过它们存在的间接证据;化学捕集和质谱学现在为这些关键中间体提供了直接和明确的证据。
Two proposed mechanisms for 4-thiouridine generation share key cysteine persulfide and disulfide intermediates, and indirect evidence of their existence has been previously reported; chemical trapping and mass spectrometry have now provided direct and definitive evidence of these key intermediates.
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