An analysis framework for the integration of broadband NIRS and EEG to assess neurovascular and neurometabolic coupling.
An analysis framework for the integration of broadband NIRS and EEG to assess neurovascular and neurometabolic coupling.
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DOI：
10.1038/s41598-021-83420-9
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发表时间：
2021-02-17
影响因子：
4.6
通讯作者：
Tachtsidis I
中科院分区：
文献类型：
--
作者：
Pinti P;Siddiqui MF;Levy AD;Jones EJH;Tachtsidis I
随着用于研究人脑功能的基于光学的神经成像技术的快速发展，我们的研究小组一直在开发宽带近红外光谱(BNIRS)仪器，这是功能近红外光谱(FNIRS)的技术扩展。BNIRS具有监测大脑血流动力学/氧合作用(测量氧化和脱氧血红蛋白)和新陈代谢(测量细胞色素-c-氧化酶氧化还原状态的变化)的独特能力。当与脑电(EEG)相结合时，bNIRS提供了一个独特的神经监测平台来探索神经血管耦合机制。在本文中，我们提出了一种新的综合分析bNIRS和脑电信号的流水线，并展示了它在健康成人视觉刺激任务中同时记录的多通道bNIRS数据上的应用。我们介绍了有限脉冲响应函数在bNIRS的一般线性模型中的应用，并展示了其在统计上定位枕叶皮质血流动力学和代谢活动的可行性。此外，我们的结果表明，血流动力学和代谢测量的融合仅通过血流动力学成像揭示了关于大脑功能的额外信息。基于互相关的脑电(EEG)和血流动力学/代谢(BNIRS)活动之间的相互关系分析表明，bNIRS代谢信号提供了一个独特的大脑活动标记，与神经元EEG反应更紧密地耦合在一起。
With the rapid growth of optical-based neuroimaging to explore human brain functioning, our research group has been developing broadband Near Infrared Spectroscopy (bNIRS) instruments, a technological extension to functional Near Infrared Spectroscopy (fNIRS). bNIRS has the unique capacity of monitoring brain haemodynamics/oxygenation (measuring oxygenated and deoxygenated haemoglobin), and metabolism (measuring the changes in the redox state of cytochrome-c-oxidase). When combined with electroencephalography (EEG), bNIRS provides a unique neuromonitoring platform to explore neurovascular coupling mechanisms. In this paper, we present a novel pipeline for the integrated analysis of bNIRS and EEG signals, and demonstrate its use on multi-channel bNIRS data recorded with concurrent EEG on healthy adults during a visual stimulation task. We introduce the use of the Finite Impulse Response functions within the General Linear Model for bNIRS and show its feasibility to statistically localize the haemodynamic and metabolic activity in the occipital cortex. Moreover, our results suggest that the fusion of haemodynamic and metabolic measures unveils additional information on brain functioning over haemodynamic imaging alone. The cross-correlation-based analysis of interrelationships between electrical (EEG) and haemodynamic/metabolic (bNIRS) activity revealed that the bNIRS metabolic signal offers a unique marker of brain activity, being more closely coupled to the neuronal EEG response.
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同时功能性近红外光谱和脑电图，以监测人脑活动和氧合的监测：综述。
影响因子：
5.3
作者：
Chiarelli AM;Zappasodi F;Di Pompeo F;Merla A
通讯作者：
Merla A
影响因子：
2.9
作者：
MATCHER, SJ;ELWELL, CE;DELPY, DT
通讯作者：
DELPY, DT
影响因子：
56.9
作者：
Niessing, J;Ebisch, B;Galuske, RAW
通讯作者：
Galuske, RAW
影响因子：
3.4
作者：
Kolyva, Christina;Tachtsidis, Ilias;Elwell, Clare E.
通讯作者：
Elwell, Clare E.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y