X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells.
X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells.
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DOI:
10.1038/srep00610
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发表时间:
2012
影响因子:
4.6
通讯作者:
Margaritondo, G.
中科院分区:
文献类型:
--
作者:
Chien, Chia-Chi;Chen, Hsiang-Hsin;Lai, Sheng-Feng;Hwu, Y.;Petibois, Cyril;Yang, C. S.;Chu, Y.;Margaritondo, G.
We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.
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影响因子:
10.2
作者:
Chen HH;Chien CC;Petibois C;Wang CL;Chu YS;Lai SF;Hua TE;Chen YY;Cai X;Kempson IM;Hwu Y;Margaritondo G
通讯作者:
Margaritondo G
影响因子:
3.5
作者:
Hwu, Y;Tsai, WL;Seong, JK
通讯作者:
Seong, JK
影响因子:
78.8
作者:
Jain, Rakesh K.;Stylianopoulos, Triantafyllos
通讯作者:
Stylianopoulos, Triantafyllos
影响因子:
3.3
作者:
Hall, C. J.;Schultke, E.;Juurlink, B. H. J.
通讯作者:
Juurlink, B. H. J.
影响因子:
3.2
作者:
Hwu, Y;Hsieh, HH;Margaritondo, G
通讯作者:
Margaritondo, G