The JUUL E-Cigarette Elevates the Risk of Thrombosis and Potentiates Platelet Activation.
The JUUL E-Cigarette Elevates the Risk of Thrombosis and Potentiates Platelet Activation.
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DOI：
10.1177/1074248420941681
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发表时间：
2020-11
影响因子：
2.6
通讯作者：
Alshbool FZ
中科院分区：
文献类型：
--
作者：
Ramirez JEM;Karim ZA;Alarabi AB;Hernandez KR;Taleb ZB;Rivera JO;Khasawneh FT;Alshbool FZ
吸烟是美国和世界范围内可预防的主要死亡原因，并与严重的心血管健康后果有关，包括血栓性疾病。最近，电子烟（电子烟），特别是JUUL，在吸烟者、非吸烟者、孕妇甚至年轻人中广泛流行，这令人担忧。有趣的是，没有关于JUUL对心血管疾病的影响的信息/研究，特别是在血小板活化调节的背景下。因此，重要的是要识别与JUUL相关的心血管疾病健康风险。我们使用了一种被动电子烟蒸汽吸入系统，其中C57 BL/6 J小鼠（10-12周龄）暴露于JUUL电子烟蒸汽。含有5重量%尼古丁的薄荷味JUUL豆荚用作电子液体。小鼠每天暴露于总共70次抽吸，持续2周; 3秒抽吸持续时间和25秒抽吸间隔。分析了JUUL相对于清洁空气对体外（例如，聚集）和体内（例如，FeCl 3诱导的颈动脉损伤血栓形成模型）小鼠血小板功能的影响。我们的研究结果表明，相对于清洁空气，短期暴露于JUUL电子烟会导致血小板过度活化，缩短血栓闭塞和止血/出血时间（中位数分别为14秒与200秒，P <0.01和35秒与295秒，P <0.001）。我们的研究结果首次证明，短期接触JUUL电子烟会增加血栓形成事件的风险，部分原因是通过调节小鼠的血小板功能，如聚集和分泌。
Smoking is the main preventable cause of death in the United States and worldwide and is associated with serious cardiovascular health consequences, including thrombotic diseases. Recently, electronic cigarettes (e-cigarettes) and, in particular JUUL, have attained wide popularity among smokers, nonsmokers, pregnant females, and even the youth, which is alarming. Interestingly, there is/are no information/studies regarding the effect of JUUL on cardiovascular diseases, specifically in the context of modulation of platelet activation. Thus, it is important to discern the cardiovascular disease health risks associated with JUUL. We used a passive e-vape vapor inhalation system where C57BL/6J mice (10-12 weeks old) were exposed to JUUL e-cigarette vape. Menthol flavored JUUL pods containing 5% nicotine by weight were used as the e-liquid. Mice were exposed to a total of 70 puffs daily for 2 weeks; 3-second puff duration, and 25-second puff interval. The effects of JUUL relative to clean air were analyzed, on mouse platelet function in vitro (eg, aggregation) and in vivo (eg, FeCl3-induced carotid artery injury thrombosis model). Our results indicate that short-term exposure to JUUL e-cigarette causes hyperactivation of platelets and shortens the thrombus occlusion as well as hemostasis/bleeding times, relative to clean air (medians of 14 vs. 200 seconds, P < .01 and 35 vs. 295 seconds, P < .001, respectively). Our findings document—for the first time—that short-term exposure to the JUUL e-cigarette increases the risk of thrombotic events, in part by modulating platelet function, such as aggregation and secretion, in mice.
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影响因子：
4.2
作者：
Brett, Emma I.;Stevens, Elise M.;Hebert, Emily T.
通讯作者：
Hebert, Emily T.
影响因子：
3.2
作者：
Ljungberg, Liza U.;Persson, Karin;Whiss, Per A.
通讯作者：
Whiss, Per A.
影响因子：
13.8
作者：
McKelvey, Karma;Baiocchi, Mike;Halpern-Felsher, Bonnie
通讯作者：
Halpern-Felsher, Bonnie
影响因子：
5.2
作者：
Huang J;Duan Z;Kwok J;Binns S;Vera LE;Kim Y;Szczypka G;Emery SL
通讯作者：
Emery SL
影响因子：
2.7
作者：
Kroon, Lisa A.
通讯作者：
Kroon, Lisa A.