Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice.
Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice.
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DOI：
10.1016/j.pbb.2013.07.008
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发表时间：
2013-09
影响因子：
3.6
通讯作者：
Griffin, William C., III
中科院分区：
文献类型：
--
作者：
Hilbert, Megan L. T.;May, Christina E.;Griffin, William C., III
乙醇饮用者，特别是年轻人，越来越多的趋势是在饮酒期间将含咖啡因的能量饮料与乙醇结合起来。这些混合剂的主要活性成分是咖啡因，它可能与乙醇发生显着相互作用。我们测试了两个假设，即咖啡因会增强乙醇条件性位置偏爱，也会增强乙醇刺激的自发活动。在C57 BL/6 J（B6）小鼠中，以1.75 g/kg乙醇和3 mg/kg咖啡因的条件性位置偏爱程序检查乙醇和咖啡因的相互作用药理学。此外，我们使用B6小鼠来评估乙醇/咖啡因组合对自发活动的影响，使用3个剂量的乙醇（1.75、2.5和3.25 g/kg）和2个剂量的咖啡因（3和15 mg/kg）。乙醇和咖啡因单独给药都增加了对药物配对侧的偏好，尽管咖啡因的作用比乙醇更温和。药物组合产生显着的位置偏好本身，但这并不大于单独的乙醇。此外，与单独给予任何一种药物相比，咖啡因和乙醇的组合显着增加了运动。刺激剂量的乙醇（1.75 g/kg）的效果最强，随着乙醇剂量的增加而减弱。因此，咖啡因和乙醇的组合在小鼠中具有显著的条件强化和运动激活作用。
A growing trend among ethanol drinkers, especially young adults, is to combine caffeinated energy drinks with ethanol during a drinking episode. The primary active ingredient of these mixers is caffeine, which may significantly interact with ethanol. We tested the two hypotheses that caffeine would enhance ethanol-conditioned place preference and also enhance ethanol-stimulated locomotor activity. The interactive pharmacology of ethanol and caffeine was examined in C57BL/6J (B6) mice in a conditioned place preference procedure with 1.75 g/kg ethanol and 3 mg/kg caffeine. Additionally, we used B6 mice to evaluate ethanol/caffeine combinations on locomotor activity using 3 doses of ethanol (1.75, 2.5 and 3.25 g/kg) and 2 two doses of caffeine (3 and 15 mg/kg). Both ethanol and caffeine administered alone increased preference for the drug paired side, though the effect of caffeine was more modest than that of ethanol. The drug combination produced significant place preference itself, but this was not greater than that for ethanol alone. Additionally, the combination of caffeine and ethanol significantly increased locomotion compared to giving either drug alone. The effect was strongest with a stimulatory dose of ethanol (1.75 g/kg) and waned with increasing doses of ethanol. Thus, combinations of caffeine and ethanol had significant conditioned reinforcing and locomotor activating effects in mice.
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影响因子：
3.4
作者：
Alford, Chris;Hamilton-Morris, Jennifer;Verster, Joris C.
通讯作者：
Verster, Joris C.
影响因子：
3.6
作者：
BUCKHOLTZ, NS;MIDDAUGH, LD
通讯作者：
MIDDAUGH, LD
影响因子：
3.6
作者：
Giles, Grace E.;Mahoney, Caroline R.;Kanarek, Robin B.
通讯作者：
Kanarek, Robin B.
DOI：
10.1111/j.1530-0277.1994.tb00894.x
发表时间：
1994-02-01
影响因子：
3.2
作者：
ISRAEL, Y;ORREGO, H;CARMICHAEL, FJ
通讯作者：
CARMICHAEL, FJ
影响因子：
3.4
作者：
Griffin, William C., III;McGovern, Robin W.;Bell, Guinevere H.;Randall, Patrick K.;Middaugh, Lawrence D.;Patrick, Kennerly S.
通讯作者：
Patrick, Kennerly S.