Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex.
Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex.
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DOI：
10.1038/s41598-021-96596-x
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发表时间：
2021-08-25
影响因子：
4.6
通讯作者：
Inohara H
中科院分区：
文献类型：
--
作者：
Harada S;Imai T;Takimoto Y;Ohta Y;Sato T;Kamakura T;Takeda N;Kitahara T;Kondo M;Ueno Y;Shimada S;Inohara H
在耳间方向，在侧向平移运动中加载平移线加速度，在侧向倾斜运动中加载重力加速度。这两种加速度通过两种类型的耳石-眼反射来补偿运动和保持清晰的视觉，从而导致眼睛运动：平移运动中的水平眼睛运动和倾斜运动中的扭曲眼睛运动(扭转)。虽然这两种加速度无法区分，但两种耳石-眼反射可以有效地区分它们。在目前的研究中，我们测试了侧眼小鼠是否同时表现出这两种耳石-眼睛反射。此外，我们还提出了一个新的指标来评估小鼠的耳石-眼反射。在侧向平移运动中，小鼠没有表现出适当的水平眼球运动，但表现出不必要的垂直扭转式眼球运动，通过将体轴和重力惯性加速度(GIA；即运动产生的重力和惯性力之和)解释为重力来补偿身体轴和重力惯性加速度之间的角度。使用新的指标(眼球运动垂直分量的幅度)/(体轴和GIA之间的夹角)，可以评估小鼠的耳石-眼反射，而不需要确定耳石-眼反射是在平移运动还是在倾斜运动中诱导的。
In the interaural direction, translational linear acceleration is loaded during lateral translational movement and gravitational acceleration is loaded during lateral tilting movement. These two types of acceleration induce eye movements via two kinds of otolith-ocular reflexes to compensate for movement and maintain clear vision: horizontal eye movement during translational movement, and torsional eye movement (torsion) during tilting movement. Although the two types of acceleration cannot be discriminated, the two otolith-ocular reflexes can distinguish them effectively. In the current study, we tested whether lateral-eyed mice exhibit both of these otolith-ocular reflexes. In addition, we propose a new index for assessing the otolith-ocular reflex in mice. During lateral translational movement, mice did not show appropriate horizontal eye movement, but exhibited unnecessary vertical torsion-like eye movement that compensated for the angle between the body axis and gravito-inertial acceleration (GIA; i.e., the sum of gravity and inertial force due to movement) by interpreting GIA as gravity. Using the new index (amplitude of vertical component of eye movement)/(angle between body axis and GIA), the mouse otolith-ocular reflex can be assessed without determining whether the otolith-ocular reflex is induced during translational movement or during tilting movement.
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DOI：
10.1523/jneurosci.1607-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu S;Angelaki DE
通讯作者：
Angelaki DE
影响因子：
2.9
作者：
Oommen, Brian S.;Stahl, John S.
通讯作者：
Stahl, John S.
影响因子：
2
作者：
BUSETTINI, C;MILES, FA;CARL, JR
通讯作者：
CARL, JR
影响因子：
4.1
作者：
Abadi, RV;Bjerre, A
通讯作者：
Bjerre, A
影响因子：
2.5
作者：
Angelaki, DE;Hess, BJM
通讯作者：
Hess, BJM