DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival.
DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival.
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DOI：
10.1016/j.oraloncology.2018.08.021
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发表时间：
2018-10
期刊：
影响因子：
4.8
通讯作者：
Relton CL
中科院分区：
文献类型：
--
作者：
Ambatipudi S;Langdon R;Richmond RC;Suderman M;Koestler DC;Kelsey KT;Kazmi N;Penfold C;Ho KM;McArdle W;Ring SM;Pring M;Waterboer T;Pawlita M;Gaunt TR;Davey Smith G;Thomas S;Ness AR;Relton CL
头颈部鳞状细胞癌（HNSCC）常与慢性全身性炎症（SI）相关。在本研究中，我们评估了由DNA甲基化衍生的SI（mdSI）指标：中性粒细胞与淋巴细胞比值（mdNLR）和淋巴细胞与单核细胞比值（mdLMR）是否与HNSCC的存在以及总生存期（OS）相关。
我们使用了两个外周血DNA甲基化数据集：一个HNSCC病例 - 对照数据集（n = 183）和一个HNSCC生存数据集（n = 407）来估算mdSI指标。然后我们进行了多元回归分析以检验mdSI指标、HNSCC的发生以及OS之间的关联。
多元逻辑回归显示，mdNLR升高与患HNSCC的几率增加相关（比值比 = 3.25，95%置信区间 = 2.14 - 5.34，P = 4×10⁻⁷），而mdLMR则呈现相反情况（比值比 = 0.88，95%置信区间 = 0.81 - 0.90，P = 2×10⁻³）。
在HNSCC生存数据集中，与血清阴性患者相比，人乳头瘤病毒16 - E6血清阳性的HNSCC患者mdLMR升高（P = 9×10⁻⁵），mdNLR降低（P = 0.003）。在HNSCC生存数据集中进行的多元Cox回归分析显示，mdLMR较低（风险比 = 1.96，95%置信区间 = 1.30 - 2.95，P = 0.0013），但mdNLR较低（风险比 = 0.68，95%置信区间 = 0.46 - 1.00，P = 0.0501）与死亡风险增加相关。
我们的研究结果表明，由DNA甲基化数据估算的mdSI与HNSCC的存在以及总生存期相关。在没有基于细胞的估算的情况下，mdSI指标可作为一种有价值的研究工具来可靠地估算SI。未来有必要在大型前瞻性研究中对我们的研究结果进行严格验证。
Head and neck squamous cell carcinoma (HNSCC) is often associated with chronic systemic inflammation (SI). In the present study, we assessed if DNA methylation-derived SI (mdSI) indices: Neutrophil-to- Lymphocyte ratio (mdNLR) and Lymphocyte-to-Monocyte ratio (mdLMR) are associated with the presence of HNSCC and overall survival (OS). We used two peripheral blood DNA methylation datasets: an HNSCC case-control dataset (n = 183) and an HNSCC survival dataset (n = 407) to estimate mdSI indices. We then performed multivariate regressions to test the association between mdSI indices, HNSCC development and OS. Multivariate logistic regression revealed that elevated mdNLR was associated with increased odds of being an HNSCC case (OR = 3.25, 95% Cl = 2.14–5.34, P = 4× 10-7) while the converse was observed for mdLMR (OR = 0.88, 95% Cl = 0.81–0.90, P = 2 × 10−3). In the HNSCC survival dataset, HPV16-E6 seropositive HNSCC cases had an elevated mdLMR (P = 9 × 10−5) and a lower mdNLR (P = 0.003) compared to seronegative patients. Multivariate Cox regression in the HNSCC survival dataset revealed that lower mdLMR (HR = 1.96, 95% Cl = 1.30–2.95, P = 0.0013) but not lower mdNLR (HR = 0.68, 95% Cl = 0.46–1.00, P = 0.0501) was associated with increased risk of death. Our results indicate that mdSI estimated by DNA methylation data is associated with the presence of HNSCC and overall survival. The mdSI indices may be used as a valuable research tool to reliably estimate SI in the absence of cell-based estimates. Rigorous validation of our findings in large prospective studies is warranted in the future.
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影响因子：
50.3
作者：
Ahn, G-One;Brown, J. Martin
通讯作者：
Brown, J. Martin
全身性炎症是口咽和非咽咽患者粘膜鳞状细胞癌的临床结果的独立预测标记。
影响因子：
3.8
作者：
Charles KA;Harris BD;Haddad CR;Clarke SJ;Guminski A;Stevens M;Dodds T;Gill AJ;Back M;Veivers D;Eade T
通讯作者：
Eade T
影响因子：
45.3
作者：
Kreimer, Aimee R.;Johansson, Mattias;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
30.8
作者：
Lesseur, Corina;Diergaarde, Brenda;Olshan, Andrew F.;Wunsch-Filho, Victor;Ness, Andrew R.;Liu, Geoffrey;Lacko, Martin;Eluf-Neto, Jose;Franceschi, Silvia;Lagiou, Pagona;Macfarlane, Gary J.;Richiardi, Lorenzo;Boccia, Stefania;Polesel, Jerry;Kjaerheim, Kristina;Zaridze, David;Johanson, Mattias;Menezes, Ana M.;Curado, Maria Paula;Robinson, Max;Ahrens, Wolfgang;Canova, Cristina;Znaor, Ariana;Castellsague, Xavier;Conway, David I.;Holcatova, Ivana;Mates, Dana;Vidensky, Marta;Healy, Claire M.;Szeszenia-Dbrowska, Neonila;Fabianova, Eleonora;Lissowska, Jolanta;Grandis, Jennifer R.;Weissler, Mark C.;Tajara, Eloiza H.;Nunes, Fabio D.;de Carvalho, Marcos B.;Thomas, Steve;Hung, Rayjean J.;Peters, Wilbert H. M.;Herrero, Rolando;Cadoni, Gabriella;Bueno-de-Mesquita, H. Bas;Steffen, Annika;Agudo, Antonio;Shangina, Oxana;Xiao, Xiangjun;Gaborieau, Valerie;Chabrier, Amelie;Anantharaman, Devasena;Boffetta, Paolo;Amos, Christopher I.;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul
DOI：
10.1002/hed.23263
发表时间：
2014-01
影响因子：
2.9
作者：
Dewyer, Nicholas A.;Wolf, Gregory T.;Light, Emily;Worden, Francis;Urba, Susan;Eisbruch, Avraham;Bradford, Carol R.;Chepeha, Douglas B.;Prince, Mark E.;Moyer, Jeffrey;Taylor, Jeremy
通讯作者：
Taylor, Jeremy