Sleep replay reveals premotor circuit structure for a skilled behavior.
Sleep replay reveals premotor circuit structure for a skilled behavior.
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DOI：
10.1016/j.neuron.2021.09.021
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发表时间：
2021-12-01
期刊：
影响因子：
16.2
通讯作者：
Long MA
中科院分区：
文献类型：
--
作者：
Elmaleh M;Kranz D;Asensio AC;Moll FW;Long MA
神经回路通常表现出一系列的活动，但局部网络对它们的产生的贡献尚不清楚。在斑马雀中，HVC内与歌唱相关的前驱运动序列可能是局部连接和来自葡萄状核(UVA)的远程丘脑输入的某种组合的结果。因为任何一种结构的损伤都会废除歌曲，所以我们使用高密度记录方法来检查“睡眠重放”，以重建与歌曲相关的精确事件。Nidopalum上游面间核损伤后，重放活动持续存在，HVC冷却时重放活动减慢，表明HVC为这些事件提供了时间结构。为了进一步衡量HVC内连接对塑造网络动态的重要性，我们在睡眠期间对UVA进行了研究，发现残留的重放序列可以跨越音节边界，支持HVC可以在歌曲持续时间内传播序列的模型。我们的结果强调了研究离线活动对于研究行为相关电路组织的力量。ElMaleh等人。使用高密度录音来测量斑马雀的歌唱控制通路的活动。他们精确地解码睡眠期间与歌曲相关的活动片段，并利用这些“离线”动态来测试负责序列生成的三种网络连接模型。
Neural circuits often exhibit sequences of activity, but the contribution of local networks to their generation remains unclear. In the zebra finch, song-related premotor sequences within HVC may result from some combination of local connectivity and long-range thalamic inputs from nucleus uvaeformis (Uva). Because lesions to either structure abolish song, we examine ‘sleep replay’ using high-density recording methods to reconstruct precise song-related events. Replay activity persists after the upstream nucleus interfacialis of the nidopallium is lesioned and slows when HVC is cooled, demonstrating that HVC provides temporal structure for these events. To further gauge the importance of intra-HVC connectivity for shaping network dynamics, we lesion Uva during sleep and find that residual replay sequences can span syllable boundaries, supporting a model in which HVC can propagate sequences throughout the duration of the song. Our results highlight the power of studying offline activity for studying behaviorally relevant circuit organization. Elmaleh et al. use high density recordings to measure the activity of the song control pathway in the zebra finch. They precisely decode snippets of song-related activity during sleep and leverage these ‘offline’ dynamics to test three models of network connectivity responsible for sequence generation.
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影响因子：
64.5
作者：
Egger R;Tupikov Y;Elmaleh M;Katlowitz KA;Benezra SE;Picardo MA;Moll F;Kornfeld J;Jin DZ;Long MA
通讯作者：
Long MA
小脑-丘脑皮质通路驱动行为环境相关的运动启动。
影响因子：
16.2
作者：
Dacre J;Colligan M;Clarke T;Ammer JJ;Schiemann J;Chamosa-Pino V;Claudi F;Harston JA;Eleftheriou C;Pakan JMP;Huang CC;Hantman AW;Rochefort NL;Duguid I
通讯作者：
Duguid I
影响因子：
1.4
作者：
CYNX, J
通讯作者：
CYNX, J
影响因子：
5.3
作者：
Cardin, JA;Schmidt, MF
通讯作者：
Schmidt, MF
影响因子：
2.5
作者：
Galvis, Daniel;Wu, Wei;Bertram, Richard
通讯作者：
Bertram, Richard