Sleep deprivation disrupts the lacrimal system and induces dry eye disease.
Sleep deprivation disrupts the lacrimal system and induces dry eye disease.
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睡眠不足会破坏泪腺系统并诱发干眼症
DOI：
10.1038/emm.2017.285
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发表时间：
2018-03-02
影响因子：
12.8
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Li S;Ning K;Zhou J;Guo Y;Zhang H;Zhu Y;Zhang L;Jia C;Chen Y;Sol Reinach P;Liu Z;Li W
睡眠不足是一个常见的公共卫生问题，与许多疾病有关，如肥胖和心血管疾病。在这项研究中，我们建立了一个睡眠剥夺(SD)小鼠的模型，并观察了睡眠不足对眼表健康的影响。我们发现SD减少了房水的泪液分泌，增加了角膜上皮细胞缺陷、角膜敏感性和细胞凋亡，并诱导了角膜上皮的鳞状化生。这些病变与干眼症的典型特征相似。SD后10d，角膜未见明显炎症反应，结膜杯状细胞未见明显改变。同时，随着SD病程的延长，泪腺肥大并伴有脂类代谢产物、分泌蛋白和游离氨基酸谱的异常。此外，SD引起的眼表变化在休息14天后基本逆转。我们的结论是，SD损害了泪道系统的功能，并导致干眼。这些发现将有助于睡眠障碍相关眼表疾病的临床诊断和治疗。
Sleep deficiency is a common public health problem associated with many diseases, such as obesity and cardiovascular disease. In this study, we established a sleep deprivation (SD) mouse model using a ‘stick over water’ method and observed the effect of sleep deficiency on ocular surface health. We found that SD decreased aqueous tear secretion; increased corneal epithelial cell defects, corneal sensitivity, and apoptosis; and induced squamous metaplasia of the corneal epithelium. These pathological changes mimic the typical features of dry eye. However, there was no obvious corneal inflammation and conjunctival goblet cell change after SD for 10 days. Meanwhile, lacrimal gland hypertrophy along with abnormal lipid metabolites, secretory proteins and free amino-acid profiles became apparent as the SD duration increased. Furthermore, the ocular surface changes induced by SD for 10 days were largely reversed after 14 days of rest. We conclude that SD compromises lacrimal system function and induces dry eye. These findings will benefit the clinical diagnosis and treatment of sleep-disorder-related ocular surface diseases.
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影响因子：
17.8
作者：
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通讯作者：
Dartt, Darlene A.
影响因子：
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