Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease.
Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease.
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DOI：
10.21037/jtd-21-259
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发表时间：
2021-04
影响因子：
2.5
通讯作者：
Tang C
中科院分区：
文献类型：
--
作者：
Sun R;Qiao Y;Yan G;Wang D;Zuo W;Ji Z;Zhang X;Yao Y;Ma G;Tang C
早期识别易损斑块对减少冠心病患者的急性冠脉事件和改善预后具有重要意义。我们试图研究脂肪细胞分泌的脂肪因子adipsin与冠心病患者斑块易损性之间的关系。通过光学相干断层扫描对来自99名接受冠状动脉造影术的连续患者的共103个斑块进行了评估。采用酶联免疫吸附试验（ELISA）测定血清中的脂蛋白酶水平。adipsin检测薄帽纤维粥样硬化（TCFA）的准确性由受试者工作特征曲线下面积（AUC）确定。在99例患者中，根据血清adipsin的中位数水平（2.43 µg/mL），49例被分为低adipsin组，50例被分为高adipsin组。与低脂蛋白组相比，高脂蛋白组斑块的脂质指数（2，700.0 vs. 1，975.9 ° × mm，P=0.015）和TCFA比例（41.2% vs. 21.2%，P=0.028）增加。血清脂蛋白酶与纤维帽厚度呈负相关（ρ=-0.322，P =0.002），而与平均血脂弧呈正相关（ρ=0.253，P=0.015），最大脂质弧（ρ=0.211，P=0.044）、脂质核心长度（ρ=0.241，P=0.021）、脂质指数（ρ=0.335，P=0.001）和脆弱性评分（ρ=0.254，P=0.014）。多因素分析显示，adipsin与TCFA有显著相关性（OR：1.290，95% CI：1.048-1.589，P=0.016），而对TCFA的诊断准确性为中等（AUC：0.710，95% CI：0.602-0.817，P<0.001）。我们的研究结果表明，血清脂蛋白酶与TCFA的发病率显着正相关。应用脂蛋白作为生物标志物可能会改善易损斑块的诊断并为CAD患者提供临床益处。
Early identification of vulnerable plaques is important for patients with coronary artery disease (CAD) to reduce acute coronary events and improve their prognosis. We sought to examine the relationship between adipsin, an adipokine secreted from adipocytes, and plaque vulnerability in CAD patients. A total of 103 plaques from 99 consecutive patients who underwent coronary angiography were assessed by optical coherence tomography. The serum level of adipsin was measured using enzyme-linked immunosorbent assay (ELISA). The accuracy of adipsin for detecting thin-cap fibroatheroma (TCFA) was determined by the area under the receiver operating characteristic curve (AUC). Of the 99 patients, 49 were classified into the low adipsin group and 50 into the high adipsin group according to the median level of serum adipsin (2.43 µg/mL). The plaques from the high adipsin group exhibited a greater lipid index (2,700.0 vs. 1,975.9° × mm, P=0.015) and an increased proportion of TCFAs (41.2% vs. 21.2%, P=0.028) compared with the low adipsin group. Serum adipsin was found to be negatively correlated with fibrous cap thickness (ρ=−0.322, P=0.002), while it was positively correlated with average lipid arc (ρ=0.253, P=0.015), maximum lipid arc (ρ=0.211, P=0.044), lipid core length (ρ=0.241, P=0.021), lipid index (ρ=0.335, P=0.001), and vulnerability score (ρ=0.254, P=0.014). Furthermore, adipsin had a significant association with TCFAs (OR: 1.290, 95% CI: 1.048–1.589, P=0.016) in the multivariate analysis, while having a moderate diagnostic accuracy for TCFAs (AUC: 0.710, 95% CI: 0.602–0.817, P<0.001). Our findings suggest that serum adipsin is significantly and positively correlated with the incidence of TCFAs. The application of adipsin as a biomarker may offer improvement in the diagnosis of vulnerable plaques and clinical benefits for CAD patients.
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影响因子：
6.7
作者：
Hertle, Elisabeth;Arts, Ilja C. W.;van Greevenbroek, Marleen M. J.
通讯作者：
van Greevenbroek, Marleen M. J.
影响因子：
9.3
作者：
Leinhase, Iris;Rozanski, Michal;Harhausen, Denise;Thurman, Joshua M.;Schmidt, Oliver I.;Hossini, Amir M.;Taha, Mohy E.;Rittirsch, Daniel;Ward, Peter A.;Holers, V. Michael;Ertel, Wolfgang;Stahel, Philip F.
通讯作者：
Stahel, Philip F.
影响因子：
24
作者：
Jia, Haibo;Abtahian, Farhad;Aguirre, Aaron D.;Lee, Stephen;Chia, Stanley;Lowe, Harry;Kato, Koji;Yonetsu, Taishi;Vergallo, Rocco;Hu, Sining;Tian, Jinwei;Lee, Hang;Park, Seung-Jung;Jang, Yang-Soo;Raffel, Owen C.;Mizuno, Kyoichi;Uemura, Shiro;Itoh, Tomonori;Kakuta, Tsunekazu;Choi, So-Yeon;Dauerman, Harold L.;Prasad, Abhiram;Toma, Catalin;McNulty, Iris;Zhang, Shaosong;Yu, Bo;Fuster, Valentine;Narula, Jagat;Virmani, Renu;Jang, Ik-Kyung
通讯作者：
Jang, Ik-Kyung
动脉粥样硬化的炎症。
DOI：
10.1161/atvbaha.108.179705
发表时间：
2012-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Libby P
通讯作者：
Libby P
影响因子：
64.5
作者：
Lo JC;Ljubicic S;Leibiger B;Kern M;Leibiger IB;Moede T;Kelly ME;Chatterjee Bhowmick D;Murano I;Cohen P;Banks AS;Khandekar MJ;Dietrich A;Flier JS;Cinti S;Blüher M;Danial NN;Berggren PO;Spiegelman BM
通讯作者：
Spiegelman BM