The hippocampus, medial prefrontal cortex, and selective memory retrieval: evidence from a rodent model of the retrieval-induced forgetting effect.
The hippocampus, medial prefrontal cortex, and selective memory retrieval: evidence from a rodent model of the retrieval-induced forgetting effect.
复制标题
DOI：
10.1002/hipo.22291
复制
发表时间：
2014-09
期刊：
影响因子：
3.5
通讯作者：
Smith, David M.
中科院分区：
文献类型：
--
作者：
Wu, Jade Q.;Peters, Greg J.;Rittner, Pedro;Cleland, Thomas A.;Smith, David M.
抑制是包括记忆在内的许多认知功能的重要组成部分。例如，检索诱发遗忘（RIF）效应发生在对学习列表中的某些项目进行额外练习时，相对于不涉及额外练习的基线条件，抑制了对未练习项目的检索。虽然违反直觉，但RIF现象对于通过抑制潜在的竞争检索目标来解决干扰可能很重要。神经影像学研究表明海马和前额皮质（PFC）参与RIF效应，但尚未进行对照病变研究。我们开发了一个RIF训练程序的啮齿动物模型，并训练了对照大鼠和海马或mPFC暂时失活的大鼠。老鼠在一系列气味线索上进行训练，这些线索被放在有埋藏奖励的挖掘介质杯中，然后用这些线索的子集进行额外的练习试验。然后，我们测试了老鼠对这些线索的记忆，以及它们与奖励的联系，方法是给它们提供含有测试气味的没有诱饵的杯子，并测量它们坚持挖掘的时间。对照大鼠表现出强烈的RIF效应，其中对未练习过的气味的记忆明显受到抑制。因此，相对于涉及相同数量训练的基线条件，使用某些气味线索的额外练习会抑制对其他气味线索的记忆。海马体或mPFC的失活都阻止了RIF的作用。我们还构建了一个表征学习电路的计算模型来模拟RIF效应。我们在这个模型中表明，类似记忆表征的“边带抑制”可以再现RIF效应，而抑制参数和学习率的改变可以再现我们在大鼠中看到的损伤效应。我们的研究结果表明，RIF效应是广泛存在的，抑制过程是记忆功能的一个重要特征。
Inhibition is an important component of many cognitive functions, including memory. For example, the retrieval-induced forgetting (RIF) effect occurs when extra practice with some items from a study list inhibits the retrieval of the non-practiced items relative to a baseline condition that does not involve extra practice. Though counterintuitive, the RIF phenomenon may be important for resolving interference by inhibiting potentially competing retrieval targets. Neuroimaging studies suggest that the hippocampus and prefrontal cortex (PFC) are involved in the RIF effect, but controlled lesion studies have not yet been performed. We developed a rodent model of the RIF training procedure and trained control rats and rats with temporary inactivation of the hippocampus or mPFC. Rats were trained on a list of odor cues, presented in cups of digging medium with a buried reward, followed by additional practice trials with a subset of the cues. We then tested the rats’ memories for the cues and their association with reward by presenting them with unbaited cups containing the test odorants and measuring how long they persisted in digging. Control rats exhibited a robust RIF effect in which memory for the non-practiced odors was significantly inhibited. Thus, extra practice with some odor cues inhibited memory for the others, relative to a baseline condition that involved an identical amount of training. Inactivation of either the hippocampus or the mPFC blocked the RIF effect. We also constructed a computational model of a representational learning circuit to simulate the RIF effect. We show in this model that ‘sideband suppression’ of similar memory representations can reproduce the RIF effect and that alteration of the suppression parameters and learning rate can reproduce the lesion effects seen in our rats. Our results suggest that the RIF effect is widespread and that inhibitory processes are an important feature of memory function.
登录
查看更多内容
影响因子：
25
作者：
Kuhl, Brice A.;Dudukovic, Nicole M.;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.
影响因子：
3.7
作者：
Johansson, Mikael;Aslan, Alp;Mecklinger, Axel
通讯作者：
Mecklinger, Axel
DOI：
10.1037/0278-7393.20.5.1063
发表时间：
1994-09-01
影响因子：
2.6
作者：
ANDERSON, MC;BJORK, RA;BJORK, EL
通讯作者：
BJORK, EL
影响因子：
3.5
作者：
Anderson, MC;Bjork, EL;Bjork, RA
通讯作者：
Bjork, RA
影响因子：
64.8
作者：
Anderson, MC;Green, C
通讯作者：
Green, C