Evidencing a place for the hippocampus within the core scene processing network.
Evidencing a place for the hippocampus within the core scene processing network.
复制标题
DOI：
10.1002/hbm.23275
复制
发表时间：
2016-11
影响因子：
4.8
通讯作者：
Graham, K. S.
中科院分区：
文献类型：
--
作者：
Hodgetts, C. J.;Shine, J. P.;Lawrence, A. D.;Downing, P. E.;Graham, K. S.
关键词：
功能性神经影像学研究已经确定了几个“核心”脑区，优先激活的场景刺激，即后海马旁回（PHG），压后皮质（RSC），枕横沟（TOS）。海马体（HC）也被认为在场景处理中起着关键作用，尽管还没有研究调查HC相对于其他“核心”区域的场景敏感性。在这里，我们通过分析一个大型数据集（n = 51）来表征这些区域内个体场景偏好反应的频率和一致性，在该数据集中，参与者对场景，物体和杂乱物体进行了一次工作记忆任务。通过将独立定义的解剖ROI应用于不同体素阈值和空间滤波器的个体水平功能数据，采用无偏方法。结果发现，大多数受试者在PHG（最大= 100%的参与者），RSC（最大= 76%）和TOS（最大= 94%）中具有优先场景集群。相当数量的个体在其各自定义的HC ROI（最大= 88%）内也具有显著的场景相关聚类，证明HC对场景处理的贡献。虽然单个聚类的概率重叠图显示重叠“峰值”接近组水平分析中确定的峰值（特别是TOS和HC），但个体间一致性因地区和统计阈值而异。这些分析所揭示的区域间和个体间的差异性对功能性神经影像学研究中场景敏感皮层的定位和询问方式具有影响，特别是在内侧颞叶区域，如HC。《脑地图》37：3779-3794，2016年。© 2016 Wiley Periodicals，Inc.
Functional neuroimaging studies have identified several “core” brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene‐sensitivity in the HC relative to these other “core” regions. Here, we characterised the frequency and consistency of individual scene‐preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one‐back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently‐defined anatomical ROIs to individual‐level functional data across different voxel‐wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene‐related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap “peaks” were close to those identified in group‐level analyses (particularly for TOS and HC), inter‐individual consistency varied across regions and statistical thresholds. The inter‐regional and inter‐individual variability revealed by these analyses has implications for how scene‐sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the HC. Hum Brain Mapp 37:3779–3794, 2016. © 2016 Wiley Periodicals, Inc.
登录
查看更多内容
影响因子：
3.5
作者：
Barense, Morgan D.;Henson, Richard N. A.;Lee, Andy C. H.;Graham, Kim S.
通讯作者：
Graham, Kim S.
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.3
作者：
Downing, Paul E.;Wiggett, Alison J.;Peelen, Marius V.
通讯作者：
Peelen, Marius V.
影响因子：
64.8
作者：
Ekstrom, AD;Kahana, MJ;Fried, I
通讯作者：
Fried, I