Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint.
Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint.
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DOI：
10.1002/hipo.20641
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发表时间：
2010-03
期刊：
影响因子：
3.5
通讯作者：
Graham, Kim S.
中科院分区：
文献类型：
--
作者：
Barense, Morgan D.;Henson, Richard N. A.;Lee, Andy C. H.;Graham, Kim S.
内侧颞叶（MTL）是一组紧密相连的结构，包括海马和下面的内嗅、嗅周和海马旁皮质，传统上被认为是专门用于陈述性记忆的单一系统的一部分。然而，最近的研究表明，知觉障碍与MTL损伤的健忘症个体，海马病变引起的场景歧视赤字，和嗅周病变引起的对象和面对歧视赤字。对这些任务的损害程度的影响，需要处理复杂的连接的功能：歧视，需要多个视觉功能的整合造成赤字，而歧视，可以解决的基础上，一个单一的功能没有。在这里，我们解决这些问题与功能性神经影像学在健康参与者，因为他们进行了一个版本的古怪的歧视任务，以前在患者中使用。三种不同类型的刺激（面孔，场景，新奇的物体），从相同或不同的观点。与对患者的研究一致，我们观察到当参与者区分从不同角度呈现的面孔和物体时，与相同的观点相比，鼻周活动增加。相比之下，后部海马体对面孔和场景都表现出视角的影响。这些研究结果提供了收敛的证据表明，MTL参与的过程超出了长期的陈述性记忆，并建议这些结构在整合复杂的功能的面孔，物体和场景到视图不变的，抽象的表示的关键作用。
The medial temporal lobe (MTL), a set of heavily inter-connected structures including the hippocampus and underlying entorhinal, perirhinal and parahippocampal cortex, is traditionally believed to be part of a unitary system dedicated to declarative memory. Recent studies, however, demonstrated perceptual impairments in amnesic individuals with MTL damage, with hippocampal lesions causing scene discrimination deficits, and perirhinal lesions causing object and face discrimination deficits. The degree of impairment on these tasks was influenced by the need to process complex conjunctions of features: discriminations requiring the integration of multiple visual features caused deficits, whereas discriminations that could be solved on the basis of a single feature did not. Here, we address these issues with functional neuroimaging in healthy participants as they performed a version of the oddity discrimination task used previously in patients. Three different types of stimuli (faces, scenes, novel objects) were presented from either identical or different viewpoints. Consistent with studies in patients, we observed increased perirhinal activity when participants distinguished between faces and objects presented from different, compared to identical, viewpoints. The posterior hippocampus, by contrast, showed an effect of viewpoint for both faces and scenes. These findings provide convergent evidence that the MTL is involved in processes beyond long-term declarative memory and suggest a critical role for these structures in integrating complex features of faces, objects, and scenes into view-invariant, abstract representations.
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