Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy.
Impaired resting-state functional integrations within default mode network of generalized tonic-clonic seizures epilepsy.
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DOI：
10.1371/journal.pone.0017294
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发表时间：
2011-02-25
期刊：
影响因子：
3.7
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Song M;Du H;Wu N;Hou B;Wu G;Wang J;Feng H;Jiang T
全身性强直-阵挛发作（GTCS）的特征是无反应性和惊厥，导致意识完全丧失。近年来的研究发现，GTCS癫痫患者发作时的脑活动改变主要集中在丘脑、上脑干、内侧前额叶、后中脑和外侧顶叶等脑区。值得注意的是，这些受影响的大脑区域中有许多是相同的，并且与所谓的默认模式网络（DMN）的组成部分有相当大的重叠。在这里，我们假设GTC癫痫患者DMN的大脑活动与正常对照不同，即使在静息状态下也是如此。为了验证这一假设，我们使用静息态功能磁共振成像比较了GTCS癫痫患者和对照组的DMN。在DMN中的13个脑区被提取出来，并使用一个完整的无向加权图来模拟每个参与者的DMN。当直接比较图的边缘时，我们发现与对照组相比，GTCS癫痫患者的DMN内的功能连接性显著降低。对于图中的节点，我们发现GTCS癫痫患者DMN内的某些脑区的程度显著降低，包括前内侧前额叶皮质、双侧上级额叶皮质和后扣带回皮质。本研究探讨了GTCS癫痫引起DMN功能整合减少的可能机制。提示GTCS癫痫患者即使在静息状态下DMN的功能整合也受到损害，这有助于理解GTCS癫痫患者意识损害的神经相关性。
Generalized tonic-clonic seizures (GTCS) are characterized by unresponsiveness and convulsions, which cause complete loss of consciousness. Many recent studies have found that the ictal alterations in brain activity of the GTCS epilepsy patients are focally involved in some brain regions, including thalamus, upper brainstem, medial prefrontal cortex, posterior midbrain regions, and lateral parietal cortex. Notably, many of these affected brain regions are the same and overlap considerably with the components of the so-called default mode network (DMN). Here, we hypothesize that the brain activity of the DMN of the GTCS epilepsy patients are different from normal controls, even in the resting state. To test this hypothesis, we compared the DMN of the GTCS epilepsy patients and the controls using the resting state functional magnetic resonance imaging. Thirteen brain areas in the DMN were extracted, and a complete undirected weighted graph was used to model the DMN for each participant. When directly comparing the edges of the graph, we found significant decreased functional connectivities within the DMN of the GTCS epilepsy patients comparing to the controls. As for the nodes of the graph, we found that the degree of some brain areas within the DMN was significantly reduced in the GTCS epilepsy patients, including the anterior medial prefrontal cortex, the bilateral superior frontal cortex, and the posterior cingulate cortex. Then we investigated into possible mechanisms of how GTCS epilepsy could cause the reduction of the functional integrations of DMN. We suggested the damaged functional integrations of the DMN in the GTCS epilepsy patients even during the resting state, which could help to understand the neural correlations of the impaired consciousness of GTCS epilepsy patients.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.0900924106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Larson-Prior, Linda J.;Zempel, John M.;Raichle, Marcus E.
通讯作者：
Raichle, Marcus E.
影响因子：
3.2
作者：
Elger, CE;Bauer, J
通讯作者：
Bauer, J
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Hamandi, Khalid;Salek-Haddadi, Afraim;Lemieux, Louis
通讯作者：
Lemieux, Louis