Typicality of words produced on a semantic fluency task in amnesic mild cognitive impairment: linguistic analysis and risk of conversion to dementia.
Typicality of words produced on a semantic fluency task in amnesic mild cognitive impairment: linguistic analysis and risk of conversion to dementia.
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遗忘性轻度认知障碍中语义流畅性任务产生的单词的典型性：语言分析和转化为痴呆的风险。
DOI：
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
D. Quaranta
中科院分区：
文献类型：
--
作者：
M. Vita;C. Marra;P. Spinelli;Alessia Caprara;E. Scaricamazza;Diana Castelli;Serena Canulli;G. Gainotti;D. Quaranta
语义和，在较小程度上，语音言语流畅性任务受损的阿尔茨海默氏病（AD）和健忘症轻度认知障碍（aMCI）。此外，这两个流畅性任务已被认为是从aMCI转换为AD的可能标志。直到最近几年，流利性任务的使用一直局限于字数，但最近，语言变量，如词频，年龄的收购，熟悉度和典型性，也被考虑。特别是，注意力一直集中在典型性的词语产生的语义言语流畅性任务，因为倾向于只产生更典型的成员的各种类别点的语义记忆。我们研究的目的是比较aMCI，AD和对照组的词汇（词频）和词汇语义变量（项目典型性）在语义语言流畅性任务，并评估这些变量在预测转换的可能价值从aMCI到AD在2年的随访期。我们发现，平均典型性的话所产生的aMCI和AD科目没有差异，而这两组产生的话更高的平均典型性比对照组。此外，为了评估典型性值与转化为AD的风险之间的关系，将aMCI组分为两个亚组，包括平均典型性值低于或高于整个aMCI组中位值的受试者。与我们的假设相一致，高典型性受试者转化为AD的频率明显高于低典型性受试者。
Semantic and, to a lesser extent, phonological verbal fluency tasks are impaired in Alzheimer's disease (AD) and in amnesic mild cognitive impairment (aMCI). Furthermore, both fluency tasks have been considered as possible markers of conversion from aMCI to AD. Up to recent years, the use of fluency tasks has been limited to word count, but, more recently, linguistic variables, such as word frequency, age of acquisition, familiarity, and typicality, have also been considered. In particular, attention has been focused on typicality of words produced on semantic verbal fluency tasks, because the tendency to produce only the more typical members of various categories points to an impoverishment of semantic memory. The aim of our study was to compare in aMCI, AD, and control subjects a lexical (word frequency) and a lexical-semantic variable (item typicality) in a semantic verbal fluency task, and to evaluate the possible value of these variables in predicting conversion from aMCI to AD during a 2 years follow-up period. We found no difference in mean typicality of words produced by aMCI and AD subjects whereas both groups produced words of higher mean typicality than control subjects. Furthermore, to assess the relationship between typicality values and risk of conversion to AD, the aMCI group was split in two subgroups, including subjects who obtained a mean typicality value lower or higher than the median value of the whole aMCI group. Consistent with our hypothesis, conversion to AD was significantly more frequent in high typicality than in low typicality subjects.
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影响因子：
11
作者：
HODGES, JR;SALMON, DP;BUTTERS, N
通讯作者：
BUTTERS, N
阿尔茨海默病对言语流利性任务中项目输出的影响。
DOI：
10.1037/0894-4105.18.2.306
发表时间：
2004
期刊：
Neuropsychology.
影响因子：
--
作者：
Sailor,Kevin;Antoine,Miriam;Diaz,Michael;Kuslansky,Gail;Kluger,Alan
通讯作者：
Kluger,Alan
影响因子：
2.6
作者：
Nutter-Upham, Katherine E.;Saykin, Andrew J.;Flashman, Laura A.
通讯作者：
Flashman, Laura A.
影响因子：
5
作者：
FAZEKAS, F;CHAWLUK, JB;ZIMMERMAN, RA
通讯作者：
ZIMMERMAN, RA
影响因子：
14.5
作者：
Rascovsky, Katya;Hodges, John R.;Miller, Bruce L.
通讯作者：
Miller, Bruce L.