Neuroendocrine mechanisms of acupuncture in the treatment of hypertension.
Neuroendocrine mechanisms of acupuncture in the treatment of hypertension.
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DOI：
10.1155/2012/878673
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Longhurst JC
中科院分区：
文献类型：
--
作者：
Zhou W;Longhurst JC
高血压影响全球约 10 亿人。 药物治疗尚未完善，并且常常伴有不良副作用。针灸被用作许多心血管疾病（如高血压）的辅助治疗。人们早已确定，系统性高血压的两个主要因素是肾内肾素-血管紧张素系统和交感神经系统的慢性激活。最近的证据表明，在一些心血管疾病模型中，阻断延髓头端腹外侧 (rVLM) 中的 AT1 受体会降低交感神经活动和血压，这表明该核中血管紧张素系统的过度活跃可能在高血压的维持中发挥作用。我们的实验研究表明，在内脏反射刺激诱发的高血压模型中，电针刺激可激活弓状核、腹外侧灰质和中缝核的神经元，从而抑制 rVLM 的神经活动。本文将讨论目前关于针灸对中枢神经系统的影响的知识，以及它们如何促进针灸对内分泌系统的调节，为利用这种古老技术治疗高血压的未来提供前景。
Hypertension affects approximately 1 billion individuals worldwide. Pharmacological therapy has not been perfected and often is associated with adverse side effects. Acupuncture is used as an adjunctive treatment for a number of cardiovascular diseases like hypertension. It has long been established that the two major contributors to systemic hypertension are the intrarenal renin-angiotensin system and chronic activation of the sympathetic nervous system. Recent evidence indicates that in some models of cardiovascular disease, blockade of AT1 receptors in the rostral ventrolateral medulla (rVLM) reduces sympathetic nerve activity and blood pressure, suggesting that overactivity of the angiotensin system in this nucleus may play a role in the maintenance of hypertension. Our experimental studies have shown that electroacupuncture stimulation activates neurons in the arcuate nucleus, ventrolateral gray, and nucleus raphe to inhibit the neural activity in the rVLM in a model of visceral reflex stimulation-induced hypertension. This paper will discuss current knowledge of the effects of acupuncture on central nervous system and how they contribute to regulation of acupuncture on the endocrine system to provide a perspective on the future of treatment of hypertension with this ancient technique.
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3.3
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