Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice.
Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in mice.
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DOI：
10.1038/ijo.2010.63
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发表时间：
2010-11
影响因子：
4.9
通讯作者：
Young, M. E.
中科院分区：
文献类型：
--
作者：
Bray, M. S.;Tsai, J-Y;Villegas-Montoya, C.;Boland, B. B.;Blasier, Z.;Egbejimi, O.;Kueht, M.;Young, M. E.
热量摄入过多与肥胖、葡萄糖耐受不良、胰岛素抵抗、血脂异常和高瘦素血症（即心脏代谢综合征）的发生密切相关。研究工作主要将注意力集中在摄入卡路里的质量（即营养成分）和/或数量上，作为饮食诱发病理的潜在原因。尽管人们越来越认识到生物节律深刻影响能量稳态，但人们对营养摄入时间如何影响常见代谢疾病的发展知之甚少。检验一天中消耗膳食脂肪的时间显着影响多种心脏代谢综合征参数的假设。我们报告说，在 12 小时清醒/活动期间连续喂食低脂肪或高脂肪饮食的小鼠会适当调整食物摄入量和能量消耗，从而使代谢参数保持在正常生理范围内。相反，活跃期饮食成分的波动（如人类中发生的情况）会显着影响整个身体的代谢稳态。在活跃期开始时喂食高脂肪膳食的小鼠保留了代谢灵活性，以应对活跃期后期的饮食挑战（如间接热量测定法所示）。相反，在活动期结束时摄入高脂肪膳食会导致小鼠体重增加、肥胖、葡萄糖耐受不良、高胰岛素血症、高甘油三酯血症和高瘦素血症（即心脏代谢综合征）。后者对能量/代谢稳态的扰动与每日总热量或脂肪来源的热量无关。一天中消耗碳水化合物与脂肪的时间显着影响多种心脏代谢综合征参数。
Excess caloric intake is strongly associated with the development of increased adiposity, glucose intolerance, insulin resistance, dyslipidemia, and hyperleptinemia (i.e., the cardiometabolic syndrome). Research efforts have focused attention primarily on the quality (i.e., nutritional content) and/or quantity of ingested calories as potential causes for diet-induced pathology. Despite growing acceptance that biological rhythms profoundly influence energy homeostasis, little is known regarding how the timing of nutrient ingestion influences development of common metabolic diseases. To test the hypothesis that the time of day at which dietary fat is consumed significantly influences multiple cardiometabolic syndrome parameters. We report that mice fed either low or high fat diets in a contiguous fashion during the 12 hour awake/active period adjust both food intake and energy expenditure appropriately, such that metabolic parameters are maintained within a normal physiologic range. In contrast, fluctuation in dietary composition during the active period (as occurs in humans) markedly influences whole body metabolic homeostasis. Mice fed a high fat meal at the beginning of the active period retain metabolic flexibility in response to dietary challenges later in the active period (as revealed by indirect calorimetry). Conversely, consumption of high fat meal at the end of the active phase leads to increased weight gain, adiposity, glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and hyperleptinemia (i.e., cardiometabolic syndrome) in mice. The latter perturbations in energy/metabolic homeostasis are independent of daily total or fat-derived calories. The time-of-day at which carbohydrate versus fat is consumed markedly influences multiple cardiometabolic syndrome parameters.
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影响因子：
4.2
作者：
de Castro, JM
通讯作者：
de Castro, JM
DOI：
10.1080/07315724.2003.10719307
发表时间：
2003-08-01
影响因子：
3.5
作者：
Cho, S;Dietrich, M;Block, G
通讯作者：
Block, G
影响因子：
56.9
作者：
Turek, FW;Joshu, C;Bass, J
通讯作者：
Bass, J
影响因子：
3.5
作者：
Schibler, U;Ripperger, J;Brown, SA
通讯作者：
Brown, SA
食物摄入的昼夜节律时间有助于体重增加。
影响因子：
6.9
作者：
Arble, Deanna M.;Bass, Joseph;Laposky, Aaron D.;Vitaterna, Martha H.;Turek, Fred W.
通讯作者：
Turek, Fred W.