Case-Finding Strategies for Drug-Resistant Tuberculosis: Protocol for a Scoping Review.
Case-Finding Strategies for Drug-Resistant Tuberculosis: Protocol for a Scoping Review.
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DOI：
10.2196/40009
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发表时间：
2022-12-15
影响因子：
1.7
通讯作者：
Claassens, Mareli
中科院分区：
文献类型：
--
作者：
Van Wyk, Susanna S.;Nliwasa, Marriott;Seddon, James A.;Hoddinott, Graeme;Viljoen, Lario;Nepolo, Emmanuel;Guenther, Gunar;Ruswa, Nunurai;Lin, Hsien-Ho;Niemann, Stefan;Gandhi, Neel R.;Shah, N. Sarita;Claassens, Mareli
关键词：
耐药结核病（DR-TB）的传播仍在继续。发现耐药结核病患者并尽早开始治疗对于改善患者临床结果和打破传播链以控制大流行非常重要。据我们所知，尚未开展评估耐药结核病不同病例发现策略的有效性、成本效益、可接受性和可行性的系统评价，以为研究、政策和实践提供信息，而且尚不清楚是否存在足够的研究来进行此类评价。尚不清楚耐药结核病和药敏结核病的病例发现策略是否相似，也不清楚我们是否可以利用药敏审查的发现来为耐药结核病的病例发现策略决策提供信息。本协议旨在描述关于耐药结核病病例发现的现有文献，并描述病例发现策略。我们将筛选系统评价、试验、定性研究、诊断测试准确性研究和其他专门寻求改善耐药结核病病例发现的初步研究。我们将排除邀请因结核病症状寻求治疗的个人、包括已诊断患有结核病的个人或基于实验室的研究的研究。我们将搜索学术数据库，包括MEDLINE， Embase, the Cochrane Library, Africa-Wide Information， CINAHL， Epistemonikos和PROSPERO，没有语言和日期限制。我们将筛选标题、摘要和全文文章一式两份。数据提取和分析将使用Excel （Microsoft Corp .）进行。我们将提供一份叙述性的报告，用辅助的数字或表格来总结数据。一个基于系统的逻辑模型，从药物敏感结核病病例发现策略的综合发展而来，将被用作描述不同策略、产生的途径和途径增强的框架。搜寻工作将于2021年底进行。2022年1月至6月进行标题和摘要筛选、全文筛选和数据提取。之后，将进行分析，并汇编结果。这一范围审查将列出关于耐药结核病病例发现的现有文献，这将有助于确定是否存在关于不同耐药结核病病例发现策略的有效性、成本效益、可接受性和可行性的初步研究，并将有助于为系统审查制定潜在问题。我们还将描述耐药结核病的病例发现策略，以及它们如何与药物敏感结核病的病例发现途径模型相适应。这篇综述有一些局限性。一个限制是文献中干预术语的多样化和不一致的使用，这可能导致缺少相关的研究。对干预策略的不良报告也可能导致对干预措施的误解和错误分类。最后，耐药结核病的病例发现策略可能不适合从药物敏感结核病策略发展而来的模型。然而，这种情况将为未来的研究提供一个完善模型的机会。该审查将指导进一步的研究，为耐药结核病病例发现政策和做法的决策提供信息。derr1 - 10.2196/40009
Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to improve patient clinical outcomes and to break the chain of transmission to control the pandemic. To our knowledge systematic reviews assessing effectiveness, cost-effectiveness, acceptability, and feasibility of different case-finding strategies for DR-TB to inform research, policy, and practice have not been conducted, and it is unknown whether enough research exists to conduct such reviews. It is unknown whether case-finding strategies are similar for DR-TB and drug-susceptible TB and whether we can draw on findings from drug-susceptible reviews to inform decisions on case-finding strategies for DR-TB. This protocol aims to describe the available literature on case-finding for DR-TB and to describe case-finding strategies. We will screen systematic reviews, trials, qualitative studies, diagnostic test accuracy studies, and other primary research that specifically sought to improve DR-TB case detection. We will exclude studies that invited individuals seeking care for TB symptoms, those including individuals already diagnosed with TB, or laboratory-based studies. We will search the academic databases including MEDLINE, Embase, The Cochrane Library, Africa-Wide Information, CINAHL, Epistemonikos, and PROSPERO with no language or date restrictions. We will screen titles, abstracts, and full-text articles in duplicate. Data extraction and analyses will be performed using Excel (Microsoft Corp). We will provide a narrative report with supporting figures or tables to summarize the data. A systems-based logic model, developed from a synthesis of case-finding strategies for drug-susceptible TB, will be used as a framework to describe different strategies, resulting pathways, and enhancements of pathways. The search will be conducted at the end of 2021. Title and abstract screening, full text screening, and data extraction will be undertaken from January to June 2022. Thereafter, analysis will be conducted, and results compiled. This scoping review will chart existing literature on case-finding for DR-TB—this will help determine whether primary studies on effectiveness, cost-effectiveness, acceptability, and feasibility of different case-finding strategies for DR-TB exist and will help formulate potential questions for a systematic review. We will also describe case-finding strategies for DR-TB and how they fit into a model of case-finding pathways for drug-susceptible TB. This review has some limitations. One limitation is the diverse, inconsistent use of intervention terminology within the literature, which may result in missing relevant studies. Poor reporting of intervention strategies may also cause misunderstanding and misclassification of interventions. Lastly, case-finding strategies for DR-TB may not fit into a model developed from strategies for drug-susceptible TB. Nevertheless, such a situation will provide an opportunity to refine the model for future research. The review will guide further research to inform decisions on case-finding policies and practices for DR-TB. DERR1-10.2196/40009
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影响因子：
5.2
作者：
Allué-Guardia A;García JI;Torrelles JB
通讯作者：
Torrelles JB
DOI：
10.1186/1748-5908-5-69
发表时间：
2010-09-20
期刊：
Implementation science : IS
影响因子：
--
作者：
Levac D;Colquhoun H;O'Brien KK
通讯作者：
O'Brien KK
影响因子：
4
作者：
van Wyk SS;Medley N;Young T;Oliver S
通讯作者：
Oliver S
影响因子：
39.2
作者：
Tricco, Andrea C.;Lillie, Erin;Straus, Sharon E.
通讯作者：
Straus, Sharon E.
影响因子：
4
作者：
Munn Z;Peters MDJ;Stern C;Tufanaru C;McArthur A;Aromataris E
通讯作者：
Aromataris E