Foot-and-mouth disease: past, present and future.
Foot-and-mouth disease: past, present and future.
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DOI：
10.1186/1297-9716-44-116
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发表时间：
2013-12-05
影响因子：
4.4
通讯作者：
Belsham GJ
中科院分区：
文献类型：
--
作者：
Jamal SM;Belsham GJ
口蹄疫（FMD）是偶蹄类动物（包括牛、猪、羊和许多野生动物）的高度传染性疾病。当入侵通常没有疾病的国家时，可能会造成巨大的经济损失。此外，由于动物生产力下降和动物产品国际贸易受到限制，该病在该病流行的国家内也会产生长期影响。该疾病是由口蹄疫病毒（FMDV）（一种小核糖核酸病毒）感染引起的。已鉴定出 FMDV 的七种不同血清型（以及众多变种）。一些血清型的地理分布受到限制，例如Asia-1 和其他血清型（尤其是 O 血清型）出现在许多不同的地区。血清型之间不存在交叉保护，有时即使是相同血清型的疫苗所提供的保护也可能是有限的。因此，如果使用疫苗接种来控制疾病，那么表征正在传播的病毒非常重要。这篇综述描述了目前口蹄疫检测和表征的方法。序列信息越来越多地用于识别爆发源。此外，此类信息可用于了解病毒株内的抗原变化。讨论了在流行地区（重点是欧亚大陆）改善该疾病控制的挑战和机遇，包括粮农组织/欧洲口蹄疫病/世界动物卫生组织渐进控制途径的作用。在流行地区更好地控制该疾病可以降低侵入无疾病地区的风险。
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals including cattle, pigs, sheep and many wildlife species. It can cause enormous economic losses when incursions occur into countries which are normally disease free. In addition, it has long-term effects within countries where the disease is endemic due to reduced animal productivity and the restrictions on international trade in animal products. The disease is caused by infection with foot-and-mouth disease virus (FMDV), a picornavirus. Seven different serotypes (and numerous variants) of FMDV have been identified. Some serotypes have a restricted geographical distribution, e.g. Asia-1, whereas others, notably serotype O, occur in many different regions. There is no cross-protection between serotypes and sometimes protection conferred by vaccines even of the same serotype can be limited. Thus it is important to characterize the viruses that are circulating if vaccination is being used for disease control. This review describes current methods for the detection and characterization of FMDVs. Sequence information is increasingly being used for identifying the source of outbreaks. In addition such information can be used to understand antigenic change within virus strains. The challenges and opportunities for improving the control of the disease within endemic settings, with a focus on Eurasia, are discussed, including the role of the FAO/EuFMD/OIE Progressive Control Pathway. Better control of the disease in endemic areas reduces the risk of incursions into disease-free regions.
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影响因子：
11.8
作者：
Ayelet G;Mahapatra M;Gelaye E;Egziabher BG;Rufeal T;Sahle M;Ferris NP;Wadsworth J;Hutchings GH;Knowles NJ
通讯作者：
Knowles NJ
DOI：
10.2460/javma.2002.220.1636
发表时间：
2002-06-01
期刊：
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
影响因子：
--
作者：
Callahan, JD;Brown, F;Nelson, WM
通讯作者：
Nelson, WM
DOI：
10.1073/pnas.85.18.6811
发表时间：
1988-09-01
影响因子：
11.1
作者：
DOPAZO, J;SOBRINO, F;MOYA, A
通讯作者：
MOYA, A
影响因子：
3.8
作者：
FOX, G;PARRY, NR;BROWN, F
通讯作者：
BROWN, F
影响因子：
--
作者：
DAVIE, J
通讯作者：
DAVIE, J