Genetic characterization of foot-and-mouth disease viruses, Ethiopia, 1981-2007.

Genetic characterization of foot-and-mouth disease viruses, Ethiopia, 1981-2007.
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DOI:
10.3201/eid1509.090091
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发表时间:
2009-09
影响因子:
11.8
通讯作者:
Knowles NJ
Knowles NJ
中科院分区:
医学2区
文献类型:
--
作者:
Ayelet G;Mahapatra M;Gelaye E;Egziabher BG;Rufeal T;Sahle M;Ferris NP;Wadsworth J;Hutchings GH;Knowles NJ

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病毒多样性表明这个国家有病毒储存库。口蹄疫(FMD)是撒哈拉以南非洲的地方病。为了进一步了解其复杂的流行病学,其中涉及多个病毒血清型和宿主物种,我们的特点,从1981年至2007年在埃塞俄比亚的口蹄疫疫情恢复的病毒。我们检测了7种FMDV血清型中的5种(O、A、C、南部非洲领土[SAT] 1和SAT 2)。血清型O占主导地位,其次是血清型A; 1983年后,C型不再被识别。病毒蛋白1序列的系统发育分析表明,出现了一个新的拓扑型血清型O,东非4。2007年,在埃塞俄比亚发现了SAT 1血清型,并形成了一个新的独特的拓扑型(IX),SAT 2血清型在16年的明显间隔后再次出现。病毒的多样性突出了该地区作为口蹄疫病毒储存库的作用,它们在埃塞俄比亚的持续出现将极大地影响该大陆疾病的传播和随后的控制策略。
Virus diversity indicates a virus reservoir in this country. Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent.
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