Sleep curtailment is accompanied by increased intake of calories from snacks.
Sleep curtailment is accompanied by increased intake of calories from snacks.
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DOI：
10.3945/ajcn.2008.26574
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发表时间：
2009-01
影响因子：
7.1
通讯作者：
Penev, Plamen D.
中科院分区：
文献类型：
--
作者：
Nedeltcheva, Arlet V.;Kilkus, Jennifer M.;Imperial, Jacqueline;Kasza, Kristen;Schoeller, Dale A.;Penev, Plamen D.
睡眠不足与肥胖有关，可能会改变饥饿和食欲的内分泌调节。为了验证人类睡眠减少会促进能量摄入过多的假设。11名健康志愿者（5 F/6 M;平均值± SD，年龄39 ± 5岁; BMI 26.5 ± 1.5 kg/m2）在睡眠实验室中随机完成了两次14天的停留，随意获得可口的食物和5.5或8.5小时的就寝时间。主要终点是在每个睡前条件下消耗的膳食和零食的卡路里。其他措施包括总能量消耗和24小时血清瘦素和生长激素释放肽。在5.5小时就寝时间条件下，睡眠减少了122 ± 25分钟/夜。虽然膳食摄入量保持相似（P=0.51），但睡眠限制伴随着来自零食的卡路里消耗增加（1087 ± 541与866 ± 365 kcal/天; P=0.026），碳水化合物含量更高（65与61%; P=0.04），特别是在19：00至7：00期间。这些变化与睡前5.5小时（2526 ± 537 kcal/d）与睡前8.5小时（2390 ± 369 kcal/d，P=0.58）的能量消耗显著增加无关，两种睡眠条件下血清瘦素和ghrelin无显著差异。研究结果表明，经常性的就寝时间限制可以改变人类食物摄入的数量、组成和分布，并支持这样一种观点，即在促进肥胖的环境中睡眠时间短可能会促进从零食中过度消耗能量，而不是膳食。
Short sleep is associated with obesity and may alter the endocrine regulation of hunger and appetite. To test the hypothesis that the curtailment of human sleep could promote excessive energy intake. Eleven healthy volunteers (5F/6M; mean ± SD age 39 ± 5y; BMI 26.5 ± 1.5 kg/m2) completed in random order two 14-day stays in the sleep laboratory with ad lib access to palatable food and 5.5- or 8.5-hour bedtimes. The primary endpoints were the calories from meals and snacks consumed during each bedtime condition. Additional measures included total energy expenditure and 24-hour profiles of serum leptin and ghrelin. Sleep was reduced by 122 ± 25 min/night during the 5.5-hour bedtime condition. While meal intake remained similar (P=0.51), sleep restriction was accompanied by increased consumption of calories from snacks (1087 ± 541 vs. 866 ± 365 kcal/day; P=0.026) with higher carbohydrate content (65 vs. 61%; P=0.04), particularly during the period from 19:00 to 7:00. These changes were not associated with a significant increase in energy expenditure during the 5.5-h (2526 ± 537 kcal/d) vs. 8.5-h bedtime period (2390 ± 369 kcal/d, P=0.58) and there were no significant differences in serum leptin and ghrelin between the two sleep conditions. The results indicate that recurrent bedtime restriction can modify the amount, composition, and distribution of human food intake, and support the notion that sleeping short hours in an obesity-promoting environment may facilitate the excessive consumption of energy from snacks, but not meals.
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影响因子：
29
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