Anthropometric factors in relation to risk of glioma.
Anthropometric factors in relation to risk of glioma.
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DOI：
10.1007/s10552-013-0178-0
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发表时间：
2013-05
影响因子：
2.3
通讯作者：
Nabors, L. Burton
中科院分区：
文献类型：
--
作者：
Little, Rebecca B.;Madden, Melissa H.;Thompson, Reid C.;Olson, Jeffrey J.;LaRocca, Renato V.;Pan, Edward;Browning, James E.;Egan, Kathleen M.;Nabors, L. Burton
身高增加和肥胖增加与许多癌症类型的风险增加有关，尽管很少有大型研究在神经胶质瘤中检查这些关联。我们在一项基于美国的大型病例对照研究中检查了体重和身高作为神经胶质瘤的潜在危险因素。该分析包括1，111例胶质瘤病例和1，096例社区对照。在结构化访谈中，参与者报告了他们21岁时的身高和体重，成年时的最低和最高体重，以及过去1-5年的体重。21岁时体重不足（BMI < 18.5 kg/m2）与胶质瘤发展的风险呈负相关。在男性和女性中均观察到这种保护性关联，但仅在女性中达到统计学显著性（多变量OR 0.68; 95% CI 0.48，0.96）。当将21岁时的BMI作为连续变量进行评估时，观察到每单位kg/m2增加的风险小幅但显著增加（OR 1.04; 95% CI 1.02，1.07）。成人身高、近期体重和成年期体重变化与胶质瘤风险无关。所有结果在从不吸烟者中是相似的，并且在按胶质瘤亚型分层后是一致的。目前的数据表明，成年早期的低体重与以后生活中神经胶质瘤风险的降低有关。结果与先前的研究一致，显示胶质瘤风险与正常成人体重无实质性关联。目前的研究不支持成人身高与神经胶质瘤风险的任何关联。
Increased height and greater adiposity have been linked to an increased risk of many cancer types, though few large studies have examined these associations in glioma. We examined body weight and height as potential risk factors for glioma in a large US-based case–control study. The analysis included 1,111 glioma cases and 1,096 community controls. In a structured interview, participants reported their height and weight at 21 years of age, lowest and highest weight in adulthood, and weight 1–5 years in the past. Being underweight at age 21 (BMI < 18.5 kg/m2) was inversely associated with the risk of glioma development. This protective association was observed in both men and women, but reached statistical significance in women only (multivariate OR 0.68; 95 % CI 0.48, 0.96). When BMI at age 21 was assessed as a continuous variate, a small but significant increase in risk was observed per unit increase in kg/m2 (OR 1.04; 95 % CI 1.02, 1.07). Adult height, recent body weight, and weight change in adulthood were not associated with glioma risk. All results were similar among never smokers and were consistent after stratifying by glioma subtype. The present data suggest that a low body weight in early adulthood is associated with a reduced risk of glioma later in life. Results are consistent with previous studies in showing no material association of glioma risk with usual adult body weight. The present study does not support any association of adult stature with glioma risk.
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影响因子：
4
作者：
Egan KM;Nabors LB;Olson JJ;Monteiro AN;Browning JE;Madden MH;Thompson RC
通讯作者：
Thompson RC
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ
DOI：
10.1093/annonc/mdr270
发表时间：
2012-03
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Gray L;Lee IM;Sesso HD;Batty GD
通讯作者：
Batty GD
影响因子：
7.7
作者：
Kitahara, Cari M.;Wang, Sophia S.;Rajaraman, Preetha
通讯作者：
Rajaraman, Preetha
DOI：
10.1158/1940-6207.capr-11-0014
发表时间：
2011-09
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Michaud DS;Bové G;Gallo V;Schlehofer B;Tjønneland A;Olsen A;Overvad K;Dahm CC;Teucher B;Boeing H;Steffen A;Trichopoulou A;Bamia C;Kyrozis A;Sacerdote C;Agnoli C;Palli D;Tumino R;Mattiello A;Bueno-de-Mesquita HB;Peeters PH;May AM;Barricarte A;Chirlaque MD;Dorronsoro M;José Sánchez M;Rodríguez L;Duell EJ;Hallmans G;Melin BS;Manjer J;Borgquist S;Khaw KT;Wareham N;Allen NE;Travis RC;Romieu I;Vineis P;Riboli E
通讯作者：
Riboli E