Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: the Harvard Alumni Health Study.
Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: the Harvard Alumni Health Study.
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DOI：
10.1093/annonc/mdr270
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Batty GD
中科院分区：
文献类型：
--
作者：
Gray L;Lee IM;Sesso HD;Batty GD
成年早期肥胖与随后特定恶性肿瘤发展之间的关系尚不清楚。此外，中年肥胖介导的可能性还没有得到很好的研究。在一项罕见的研究中，我们调查了成年早期身体质量指数（BMI）与几种部位特异性癌症死亡率的关系。在哈佛校友健康研究队列中，19593名男性在1914年至1952年间（平均年龄：18.4岁）在哈佛大学进行了体检，并在1962年或1966年（平均年龄= 45.1岁）返回了一份问卷。BMI用两个时间点的体重(kg)/身高（m2）计算。生命状态随访最长持续82年。所有恶性肿瘤（校正风险比[HR] = 1.11；对于成年早期BMI增加一个标准差，95%可信区间[CI]: 1.05-1.17）、肺癌（HR = 1.24; 95% CI = 1.10-1.40）和皮肤癌（HR = 1.29; 95% CI = 0.96-1.75）的死亡率梯度均为阳性。食道癌和泌尿生殖器癌也有明显的关联。中年时BMI的中介作用很小。成年早期较高的BMI似乎是几十年后某些恶性肿瘤的直接危险因素。
The association between adiposity in early adulthood and subsequent development of specific malignancies is unclear. Further, the potential for mediation by adiposity in middle age has not been well examined. In a rare study, we investigated the association of body mass index (BMI) in early adulthood with mortality from several site-specific cancers. In the Harvard Alumni Health Study cohort, 19 593 males had a physical examination at the university between 1914 and 1952 (mean age: 18.4 years) and returned a questionnaire in 1962 or 1966 (mean age = 45.1 years). BMI was computed using weight (kg)/height2 (m2) at both time points. Vital status follow up continued for a maximum of 82 years. Positive early adulthood cancer mortality gradients by BMI were found for all malignancies combined (adjusted hazard ratio [HR] = 1.11; 95% confidence interval [CI]: 1.05–1.17 for a one standard deviation increase in early adulthood BMI), and for lung (HR = 1.24; 95% CI = 1.10–1.40) and skin (HR = 1.29; 95% CI = 0.96–1.75) cancers. There were also apparent associations for cancers of the oesophagus and urogenital sites. Mediation by BMI in middle age was found to be minimal. Higher BMI in early adulthood appears to be a direct risk factor for selected malignancies several decades later.
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