A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.
A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.
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DOI：
10.1093/g3journal/jkab199
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发表时间：
2021-08-07
期刊：
影响因子：
--
通讯作者：
Keene AC
中科院分区：
文献类型：
--
作者：
Murakami K;Palermo J;Stanhope BA;Gibbs AG;Keene AC
睡眠和新陈代谢的调节是高度相互关联的，睡眠失调与代谢疾病有关，包括肥胖、糖尿病和心脏病。此外，饮食的急性和长期变化都可能影响睡眠的持续时间和质量。为了确定调节睡眠和代谢状态之间相互作用的新因素，我们对它们在调节睡眠持续时间、饥饿抵抗和饥饿依赖性睡眠调节中的作用进行了基因筛选。这种筛选确定了许多在调节睡眠、新陈代谢或两者都有潜在作用的基因。其中一个基因编码辅助离子通道UNC79，这与睡眠和饥饿抵抗的调节有关。un79基因敲除或突变会导致果蝇睡眠时间增加，并增强对饥饿的抵抗力。先前的研究表明，24小时昼夜节律的起搏器需要unc79。在这里，我们发现un79在蘑菇体内起作用，而不是在起搏器神经元中，调节睡眠时间和饥饿抵抗。总之，这些发现揭示了unc79在调节昼夜节律行为、睡眠和代谢功能方面的空间定位可分离功能。
The regulation of sleep and metabolism are highly interconnected, and dysregulation of sleep is linked to metabolic diseases that include obesity, diabetes, and heart disease. Furthermore, both acute and long-term changes in diet potently impact sleep duration and quality. To identify novel factors that modulate interactions between sleep and metabolic state, we performed a genetic screen for their roles in regulating sleep duration, starvation resistance, and starvation-dependent modulation of sleep. This screen identified a number of genes with potential roles in regulating sleep, metabolism, or both processes. One such gene encodes the auxiliary ion channel UNC79, which was implicated in both the regulation of sleep and starvation resistance. Genetic knockdown or mutation of unc79 results in flies with increased sleep duration, as well as increased starvation resistance. Previous findings have shown that unc79 is required in pacemaker for 24-hours circadian rhythms. Here, we find that unc79 functions in the mushroom body, but not pacemaker neurons, to regulate sleep duration and starvation resistance. Together, these findings reveal spatially localized separable functions of unc79 in the regulation of circadian behavior, sleep, and metabolic function.
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影响因子：
2.4
作者：
Bushey D;Hughes KA;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
10.7
作者：
Hardy, Christopher M.;Burke, Molly K.;Gibbs, Allen G.
通讯作者：
Gibbs, Allen G.
果蝇社交聚类被麻醉和腹部离子通道突变体所破坏。
DOI：
10.1111/gbb.12025
发表时间：
2013-04
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Burg ED;Langan ST;Nash HA
通讯作者：
Nash HA
影响因子：
4.4
作者：
Grandner MA;Jackson N;Gerstner JR;Knutson KL
通讯作者：
Knutson KL
影响因子：
5.6
作者：
Arble, Deanna M.;Bass, Joseph;Wright, Kenneth P.
通讯作者：
Wright, Kenneth P.