Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels.
Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels.
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低血糖和糖尿病对大鼠脑微血管燃料代谢的影响。
DOI：
10.1152/ajpendo.1988.254.3.e272
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Ruderman,NB
中科院分区：
文献类型：
--
作者：
McCall,AL;Sussman,I;Tornheim,K;Cordero,R;Ruderman,NB
在慢性糖尿病和低血糖大鼠的离体脑微血管中比较葡萄糖和β-羟基丁酸代谢。如前所述，在链脲佐菌素诱导的糖尿病大鼠中，葡萄糖氧化和转化为乳酸减少。葡萄糖代谢的减少并没有导致隔离期间糖尿病血管的选择性损伤，因为ATP水平和ATP/ADP比值与非糖尿病大鼠相似，O2消耗量增加。此外，脑微血管β-羟基丁酸的氧化被糖尿病增强。相比之下，30天前通过胰岛素瘤移植而慢性低血糖大鼠的微血管葡萄糖氧化和转化为乳酸增加了两倍以上，而β-羟基丁酸的氧化减少了50%。与胰岛素瘤大鼠不同，在通过急性胰岛素给药或通过4天胰岛素输注产生低血糖的大鼠的微血管中未观察到葡萄糖代谢的一致增加。这些结果表明，糖尿病，在某些情况下慢性低血糖，显着改变燃料代谢的脑微血管。
Glucose and beta-hydroxybutyrate metabolism were compared in isolated cerebral microvessels from chronically diabetic and hypoglycemic rats. As noted previously, glucose oxidation and conversion to lactate are diminished in rats with streptozotocin-induced diabetes. The decrease in glucose metabolism did not result from selective damage to diabetic vessels during isolation, since the ATP level and the ATP/ADP ratio were similar to those of nondiabetic rats, and O2 consumption was increased. In addition, cerebral microvessel oxidation of beta-hydroxybutyrate was enhanced by diabetes. By contrast, microvessels from rats made chronically hypoglycemic by insulinoma engrafting 30 days earlier had a more than twofold increase in glucose oxidation and conversion to lactate, whereas their oxidation of beta-hydroxybutyrate was diminished by 50%. Unlike the insulinoma rats, no consistent increase in glucose metabolism was observed in microvessels from rats made hypoglycemic either by acute insulin administration or by a 4-day infusion of insulin. These results indicate that diabetes, and under some circumstances chronic hypoglycemia, markedly alters fuel metabolism in the cerebral microvasculature.
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影响因子：
56.9
作者：
GJEDDE, A;CRONE, C
通讯作者：
CRONE, C
大脑皮质微血管：胰岛素敏感组织。
DOI：
--
发表时间：
1982
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
D. Pillion;J. Haskell;E. Meezan
通讯作者：
E. Meezan
高血压、衰老和实验性糖尿病中大鼠脑微血管的脂肪酸氧化。
影响因子：
5.3
作者：
N. Morisaki;Y. Saito;A. Kumagai
通讯作者：
A. Kumagai
早期实验性糖尿病中血脑屏障对钠的渗透性降低
影响因子：
7.7
作者：
G. Knudsen;J. Jakobsen;M. Juhler;O. Paulson
通讯作者：
O. Paulson
通过在 Leighton 管中生长的培养细胞连续测量 14C 标记的二氧化碳和乳酸。
影响因子：
2.9
作者：
A. Tercyak;H. Kuan;L. Salcedo;P. Brecher
通讯作者：
P. Brecher