Interactions between β-adrenergic vasodilation and cervical sympathetic nerves are mediated by α(2)-adrenoceptors in the rat masseter muscle.
Interactions between β-adrenergic vasodilation and cervical sympathetic nerves are mediated by α(2)-adrenoceptors in the rat masseter muscle.
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DOI：
10.1007/s12576-016-0499-3
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Sato T
中科院分区：
文献类型：
--
作者：
Ishii H;Sato T
神经和体液自主机制可能是重要的，在咬肌（MBF）的血流维持。然而，它们之间的相互作用仍不清楚。在这项研究中，我们研究了MBF的神经和体液调节之间的相互作用，并研究了介导这些相互作用的机制在麻醉大鼠。刺激肾上腺髓质的肾上腺神经（AN）可使MBF增加，这种增加是由β-肾上腺素能受体介导的。切断上级颈交感干（CST）显着抑制MBF的增加，在高活动期间，在CST的AN刺激诱导，但在低活动。在CST切片后用可乐定刺激AN可诱导MBF显著增加，而苯肾上腺素无明显作用。预处理育亨宾或普萘洛尔显着抑制MBF的增加。我们的研究结果表明，β-肾上腺素能血管扩张引起的循环肾上腺素和颈交感神经之间的相互作用，是由α2-肾上腺素受体介导的咬肌。
Neural and humoral autonomic mechanisms may be important in the maintenance of blood flow in the masseter muscle (MBF). However, their interactions remain unclear. In this study, we examined interactions between neural and humoral regulation of MBF and investigated the mechanisms mediating these interactions in urethane-anesthetized rats. Stimulation of the adrenal nerve (AN) projecting to the adrenal medulla increased MBF, and this increase was mediated by β-adrenoceptors. Sectioning of the superior cervical sympathetic trunk (CST) significantly inhibited increases in MBF induced by AN stimulation during high activity in the CST, but not during low activity. AN stimulation with clonidine after CST sectioning induced a significant increased in MBF, however phenylephrine had no observable effect. Pretreatment with yohimbine or propranolol significantly inhibited the increase in the MBF. Our results suggest an interaction between β-adrenergic vasodilation evoked by circulating adrenaline and the cervical sympathetic nerves that is mediated by α2-adrenoceptors in the masseter muscle.
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DOI：
10.1007/s00360-014-0807-2
发表时间：
2014-04-01
影响因子：
2
作者：
Ishii, Hisayoshi;Sato, Toshiya;Izumi, Hiroshi
通讯作者：
Izumi, Hiroshi
影响因子：
3
作者：
Maekawa, K;Kuboki, T;Yamashita, A
通讯作者：
Yamashita, A
影响因子：
3
作者：
Delcanho, RE;Kim, YJ;Clark, GT
通讯作者：
Clark, GT
影响因子：
3
作者：
Maekawa, K;Kuboki, T;Clark, GT
通讯作者：
Clark, GT
DOI：
10.1152/ajpregu.00866.2006
发表时间：
2007-08-01
影响因子：
2.8
作者：
Ishii, Hisayoshi;Niioka, Takeharu;Izumi, Hiroshi
通讯作者：
Izumi, Hiroshi