Potential of Gd-EOB-DTPA-enhanced MR imaging for evaluation of bile duct ligation-induced liver injury in rabbits
Potential of Gd-EOB-DTPA-enhanced MR imaging for evaluation of bile duct ligation-induced liver injury in rabbits
复制标题
Gd-EOB-DTPA 增强磁共振成像评估兔胆管结扎所致肝损伤的潜力
DOI：
10.1007/s12072-014-9595-8
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Zeng MS
中科院分区：
文献类型：
--
作者：
Ding Y;Rao SX;Chen CZ;Li RC;Zeng MS
目的评价钆塞酸的应用前景采用Gd-EOB-DTPA增强MRI技术，通过T1弛豫时间测量和首过灌注分析，评价胆管结扎（BDL）所致肝损伤的动物模型。术后第5天BDL组（BDL-5d组），n= 8;术后第14天BDL组（BDL-14 d组），n= 8。在Gd-EOB-DTPA给药前和给药后20 min [肝胆期（HBP）]进行双翻转角三维梯度回波序列和容积内插屏气检查。MRI早期动态增强扫描时间4.32 min，时间分辨率2.2 s。结果BDL-14 d组肝内胆管扩张，肝实质T1弛豫时间延长。BDL-5d组和BDL-14 d组HBP T1弛豫时间较N组显著延长（p< 0.001），增强斜率百分比较N组显著降低（p< 0.001）。BDL-5 d组与BDL-14 d组的HBP T1弛豫时间和增强斜率百分比差异无统计学意义（p> 0.05）。HBP T1弛豫时间和增强斜率百分比的受试者工作特征曲线下面积，BDL-5d组为0.98和0.92，BDL-14 d组为0.96和0.98，结论HBP T1弛豫时间测量结合首次-通过增强斜率百分比保留承诺来评估肝外螯合性肝损伤。
ObjectivesThe aim of this study was to evaluate the potential of gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI for assessment of bile duct ligation (BDL)-induced chelostatic liver injury in an animal model by T1relaxation time measurements and first-pass perfusion analyses.Materials and methodsTwenty-four rabbits were classified into three groups as follows: control group (N group),n= 8; BDL group studied on the 5th postoperative day (BDL-5d group),n= 8; BDL group studied on the 14th postoperative day (BDL-14d group),n= 8. A dual flip angle three-dimensional gradient echo sequence with volumetric interpolated breath-hold examination was performed before and at 20 min [hepatobiliary phase (HBP)] after Gd-EOB-DTPA administration. Besides, early dynamic contrast-enhanced MRI was performed for 4.32 min with a temporal resolution of 2.2 s. T1relaxation times of liver parenchyma were measured and perfusion parameters were calculated.ResultsDilatation of intra-hepatic bile duct was found only in the BDL-14d group. HBP T1relaxation times of the BDL-5d and BDL-14d groups were significantly prolonged (p< 0.001) and the enhancement slope percentage of BDL-5d and BDL-14d groups were significantly lowered in comparison with that of the N group (p< 0.001). There were no differences between the BDL-5d group and the BDL-14d group for HBP T1relaxation times and the enhancement slope percentage (p> 0.05). Area under the receiver operating characteristic curve of HBP T1relaxation time and the enhancement slope percentage for the selection of chelostatic liver were 0.98 and 0.92 for the BDL-5d group, and 0.96 and 0.98 for the BDL-14d group, respectively.ConclusionsHBP T1relaxation time measurement in combination with first-pass enhancement slope percentage withhold promise to assess extrahepatic chelostatic liver injury.
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影响因子：
25.7
作者：
Hsu, Chao-Yu;Shen, Ying-Chun;Shih, Tiffany Ting-Fang
通讯作者：
Shih, Tiffany Ting-Fang
影响因子：
4.3
作者：
Woolbright, Benjamin L.;Jaeschke, Hartmut
通讯作者：
Jaeschke, Hartmut
影响因子：
4.4
作者：
Horsthuis, Karin;Nederveen, Aart J.;Stoker, Jaap
通讯作者：
Stoker, Jaap
影响因子：
2.6
作者：
Nilsson, H.;Blomqvist, L.;Jonas, E.
通讯作者：
Jonas, E.
影响因子：
2.9
作者：
Nilsson, Henrik;Blomqvist, Lennart;Jonas, Eduard
通讯作者：
Jonas, Eduard