Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination.
Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination.
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DOI：
10.1002/hipo.20958
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发表时间：
2012-05
期刊：
影响因子：
3.5
通讯作者：
Mizumori, Sheri J. Y.
中科院分区：
文献类型：
--
作者：
Smith, David M.;Barredo, Jennifer;Mizumori, Sheri J. Y.
复杂的认知功能，如学习和记忆，是由组成功能回路的多个大脑区域相互作用产生的，这些回路的不同组成部分对学习有独特的贡献。海马体和脾后皮质(RSC)在解剖学上是相互联系的，这两个区域都参与学习和记忆。先前的研究表明，海马体在不同的背景下表现出独特的放电模式，RSC神经元选择性地对预测强化或行为反应需要的线索做出反应，这表明海马体在编码语境中扮演着角色，RSC在编码行为重要线索中扮演着重要角色。为了测试这一点，当大鼠学会区分两种行为背景时，我们同时记录了海马神经元和RSC神经元的活动。在每次实验的前半部分，大鼠学会接近正迷宫的东臂以获得奖励，在后半部分学习接近西臂。“向东去”和“向西去”的情况构成了不同的行为背景，这是由奖励地点所暗示的。随着受试者学会区分上下文，这两个区域的神经元都产生了高度特定于上下文的反应，但两个大脑区域的反应模式不同。与语境处理角色一致的是，海马神经元对各种任务刺激和事件产生语境特异性反应。相反，RSC神经元只对奖赏位置产生特定于上下文的反应，作为上下文识别线索。这些结果表明，海马体和RSC在调节与环境相适应的记忆和行为方面发挥着不同但互补的作用。
Complex cognitive functions, such as learning and memory, arise from the interaction of multiple brain regions that comprise functional circuits and different components of these circuits make unique contributions to learning. The hippocampus and the retrosplenial cortex (RSC) are anatomically interconnected and both regions are involved in learning and memory. Previous studies indicate that the hippocampus exhibits unique firing patterns for different contexts and that RSC neurons selectively respond to cues that predict reinforcement or the need for a behavioral response, suggesting a hippocampal role in encoding contexts and an RSC role in encoding behaviorally significant cues. To test this, we simultaneously recorded hippocampal and RSC neuronal activity as rats learned to discriminate two behavioral contexts. The rats learned to approach the east arm of a plus maze for reward during the first half of each session and to approach the west arm during the second half. The ‘go east’ and ‘go west’ conditions constitute distinct behavioral contexts, which were cued by the reward location. Neurons in both regions developed highly context-specific responses as subjects learned to discriminate the contexts, but the response patterns differed in the two brain regions. Consistent with a context processing role, hippocampal neurons developed context specific responses to a variety of task stimuli and events. In contrast, RSC neurons only developed context specific responses to the reward location, which served as the context identifying cue. These results suggest that the hippocampus and RSC play distinct, but complimentary roles in mediating context appropriate memories and behaviors.
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