Is it safe and effective to administer COVID-19 vaccines during pregnancy? A systematic review and meta-analysis.
Is it safe and effective to administer COVID-19 vaccines during pregnancy? A systematic review and meta-analysis.
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DOI：
10.1016/j.ajic.2022.08.014
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发表时间：
2023-05
影响因子：
4.9
通讯作者：
Siddiqi, Tariq Jamal
中科院分区：
文献类型：
--
作者：
Hameed, Ishaque;Khan, Mohammad Omer;Nusrat, Khushboo;Mahmood, Samar;Nashit, Muhammad;Malik, Shanza;Siddiqui, Omer Mustafa;Samad, Syed Abdus;Marsia, Shayan;Shariq, Muhammad;Siddiqi, Tariq Jamal
通过更新的荟萃分析评估COVID-19疫苗对孕妇的安全性和有效性。我们检索了PubMed、Cochrane Central和SCOPUS从成立到2022年3月。关注的结果是与疫苗安全性相关的母体、胎儿和新生儿不良后果的发生率。其次，我们分析了SARS-CoV-2感染人数、COVID-19住院人数和COVID-19入住重症监护病房的人数，以评估疫苗的有效性。结果采用随机效应模型汇总。纳入了10项分析孕妇的观察性研究（n= 326499）。我们的研究结果表明，COVID-19疫苗接种可有效预防感染（OR: 0.56, 95% CI: 0.47, 0.67; P = <0.00001）和相关住院（OR: 0.50, 95% CI: 0.31, 0.82; P = 0.006）。还观察到，疫苗接种不会改变妊娠不良结局，即先兆子痫或子痫、中风（分娩四周）、羊水粪染、自然阴道分娩、阴道手术分娩、剖宫产、产后出血和输血。此外，观察到该疫苗对新生儿COVID-19重症监护病房入院有保护作用（OR: 0.85; 95% CI: 0.81, 0.90; P = <0.00001）。我们的汇总分析表明，孕妇接种COVID-19疫苗可有效预防感染，无不良后果。未来需要随机的大规模试验来证实我们的结果。
To evaluate the safety and efficacy of COVID-19 vaccines in pregnant women performing an updated meta-analysis. We searched PubMed, Cochrane Central, and SCOPUS from inception to March 2022. Outcomes of interest were incidence of adverse maternal, fetal and neonatal consequences pertaining to safety of the vaccines. Secondarily, we analyzed the number of SARS-CoV-2 infections, hospitalization for COVID-19, and admission to the I.C.U. for COVID-19 assessing the effectiveness of vaccines. Results were pooled using a random effects model. Ten observational studies (n=326,499) analyzing pregnant women were included. Our results suggest that COVID-19 vaccination prevents infection (OR: 0.56, 95% CI: 0.47, 0.67; P = <0.00001) and related hospitalizations (OR: 0.50, 95% CI: 0.31, 0.82; P = 0.006) effectively. It was also observed that vaccination does not change adverse outcomes in pregnancy, namely preeclampsia or eclampsia, stroke (four weeks of delivery), meconium-stained amniotic fluid, spontaneous vaginal delivery, operative vaginal delivery, cesarean delivery, postpartum hemorrhage, and blood transfusions. Furthermore, the vaccine was observed to be protective against neonatal COVID-19 I.C.U. admissions (OR: 0.85; 95% CI: 0.81, 0.90; P = <0.00001). Our pooled analysis suggests that the COVID-19 vaccination in pregnant women prevents infection effectively and has no adverse outcomes. Future large-scale trials in a randomized fashion are needed to confirm our results.
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影响因子：
13.6
作者：
Skjefte M;Ngirbabul M;Akeju O;Escudero D;Hernandez-Diaz S;Wyszynski DF;Wu JW
通讯作者：
Wu JW
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120.7
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通讯作者：
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影响因子：
39.2
作者：
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通讯作者：
Moher, David
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作者：
Edwards, James M;Watson, Nora;Swamy, Geeta K
通讯作者：
Swamy, Geeta K
影响因子：
6.3
作者：
Theiler RN;Wick M;Mehta R;Weaver AL;Virk A;Swift M
通讯作者：
Swift M