Human papillomavirus DNA in plasma of patients with cervical cancer.
Human papillomavirus DNA in plasma of patients with cervical cancer.
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DOI：
10.1186/1471-2407-1-2
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发表时间：
2001
期刊：
影响因子：
3.8
通讯作者：
Mutirangura A
中科院分区：
文献类型：
--
作者：
Pornthanakasem W;Shotelersuk K;Termrungruanglert W;Voravud N;Niruthisard S;Mutirangura A
人乳头瘤病毒（HPV）是宫颈癌（CC）发展的关键病因。从诊断的角度来看，CC 中 HPV 的持续存在使得病毒 DNA 可以用作遗传标记。本研究的目的是评估 CC 患者循环中 HPV DNA 的存在、身体状况和临床意义。 50 名 HPV 阳性 CC 患者中有 6 名 (12%) 检测出血浆 HPV DNA，而 20 名正常对照或 13 名 HPV 阴性 CC 病例中均未检测到 HPV DNA。血浆 DNA 表现出与原发肿瘤中的 HPV 相同的 HPV 类型，并且两种来源的 DNA 都整合到宿主基因组中。有趣的是，一些研究结果表明血浆 HPV DNA 与转移之间存在关联。首先，3例HPV DNA阳性病例为临床IVB期或复发远处转移的CC患者（P = 0.001，RR = 15.67）。其次，转移患者血浆中HPV DNA的含量是其他无转移患者的三倍多。最后，与其他同期但不存在血浆HPV DNA的HPV相关CC患者相比，后来的病例在完成治疗后一年内有出现复发性远处转移的倾向。血浆 HPV DNA 源自 CC，与转移相关，可用作代表循环游离 CC DNA 的标记。
Human papillomavirus (HPV) is a crucial etiological factor for cervical cancer (CC) development. From a diagnostic view-point, the consistent presence of HPV in CC allows the viral DNA to be used as a genetic marker. The aims of this study were to evaluate the presence, physical status and clinical significant of HPV DNA in circulation of CC patients. Whereas 6 out of 50 (12%) HPV positive CC patients revealed plasma HPV DNA, it was detected in none of 20 normal controls or 13 HPV negative CC cases. The plasma DNA exhibited an HPV type identical to the HPV in the primary tumors and the DNA from both sources was integrated into host genome. Interestingly, several findings suggested an association between plasma HPV DNA and metastasis. First, three of the HPV DNA positive cases were CC patients with clinical stage IVB or recurrence with distance metastases (P = 0.001, RR = 15.67). Second, the amount of plasma HPV DNA from metastatic patients to be three times more than three other patients without metastases. Finally, the later cases had tendency to develop recurrence distant metastases within one year after complete treatment when compared with other HPV associated CC patients with the same stage but without the present of plasma HPV DNA. The plasma HPV DNA originated from the CC, was associated with metastasis and could be used as a marker representing the circulating free CC DNA.
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影响因子：
3.8
作者：
MARTELRENOIR, D;GRUNEWALD, V;JOAB, I
通讯作者：
JOAB, I
影响因子：
45.3
作者：
Pao, CC;Hor, JJ;Tseng, CJ
通讯作者：
Tseng, CJ
影响因子：
6.3
作者：
Tangkijvanich, P;Hirsch, P;Poovorawan, Y
通讯作者：
Poovorawan, Y
影响因子：
168.9
作者：
CUI, KH;WARNES, GM;MATTHEWS, CD
通讯作者：
MATTHEWS, CD
影响因子：
5.4
作者：
BAKER, CC;PHELPS, WC;HOWLEY, PM
通讯作者：
HOWLEY, PM