Predictive Ability of Pressure-Corrected Arterial Stiffness Indices: Comparison of Pulse Wave Velocity, Cardio-Ankle Vascular Index (CAVI), and CAVI0.
Predictive Ability of Pressure-Corrected Arterial Stiffness Indices: Comparison of Pulse Wave Velocity, Cardio-Ankle Vascular Index (CAVI), and CAVI0.
复制标题
DOI：
10.1093/ajh/hpab168
复制
发表时间：
2022-03-08
影响因子：
3.2
通讯作者：
Chirinos JA
中科院分区：
文献类型：
--
作者：
Spronck B;Obeid MJ;Paravathaneni M;Gadela NV;Singh G;Magro CA;Kulkarni V;Kondaveety S;Gade KC;Bhuva R;Kulick-Soper CM;Sanchez N;Akers S;Chirinos JA
脉搏波速度（PWV）是血压（BP）依赖性的，导致BP校正指标心踝血管指数（CAVI）和CAVI 0的发展。我们的目的是在美国人群中评估心脏到踝PWV（haPWV）、CAVI和CAVI 0的风险预测。我们纳入了154例有和无心力衰竭（HF）的受试者（94.8%男性; 47.7%非洲裔美国人）。使用VaSera 1500 N器械测量左右haPWV、CAVI和CAVI 0。我们对参与者进行了平均2.56年的前瞻性随访，以确定复合终点死亡或HF相关住院（DHFA）。左右侧haPWV、CAVI和CAVI 0值无显著差异。在未校正的分析中，haPWV（左侧标准化风险比[HR] = 1.51，P = 0.007;右侧HR = 1.66，P = 0.003），CAVI（左HR = 1.45，P = 0.012;右HR = 1.58，P = 0.006）和CAVI 0（左HR = 1.39，P = 0.022;右HR = 1.44，P = 0.014）显著预测DHFA。从haPWV到CAVI再到CAVI 0，预测能力呈下降趋势;与这些指标中BP校正量的增加一致。在考克斯模型中，右侧指标显示出比左侧指标更强的预测能力。校正基线HF状态后，荟萃分析慢性心力衰竭全球组（MAGGIC）风险评分和收缩压、右侧haPWV（HR = 1.58，P = 0.025）和CAVI（HR = 1.44，P = 0.044）仍具有预测性，但无其他僵硬度指标。虽然在概念上有吸引力，BP校正的动脉僵硬度指标不提供更好的预测DHFA比传统的动脉僵硬度指标，他们也不预测DHFA独立的收缩压。我们的研究结果支持PWV作为预测结果的主要动脉硬度指标。
Pulse wave velocity (PWV) is blood pressure (BP) dependent, leading to the development of the BP-corrected metrics cardio-ankle vascular index (CAVI) and CAVI0. We aimed to assess risk prediction by heart-to-ankle PWV (haPWV), CAVI, and CAVI0 in a US population. We included 154 subjects (94.8% male; 47.7% African American) with and without heart failure (HF). Left and right haPWV, CAVI, and CAVI0 were measured with the VaSera 1500N device. We prospectively followed participants for a mean of 2.56 years for the composite endpoint death or HF-related hospital admission (DHFA). Left and right haPWV, CAVI, and CAVI0 values did not differ significantly. In unadjusted analyses, haPWV (left standardized hazard ratio [HR] = 1.51, P = 0.007; right HR = 1.66, P = 0.003), CAVI (left HR = 1.45, P = 0.012; right HR = 1.58, P = 0.006), and CAVI0 (left HR = 1.39, P = 0.022; right HR = 1.44, P = 0.014) significantly predicted DHFA. Predictive ability showed a decreasing trend from haPWV to CAVI to CAVI0; in line with the increasing amount of BP correction in these metrics. In Cox models, right-sided metrics showed a trend toward stronger predictive ability than left-sided metrics. After adjustment for baseline HF status, the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score, and systolic BP, right haPWV (HR = 1.58, P = 0.025) and CAVI (HR = 1.44, P = 0.044), but no other stiffness metrics, remained predictive. Although conceptually attractive, BP-corrected arterial stiffness metrics do not offer better prediction of DHFA than conventional arterial stiffness metrics, nor do they predict DHFA independently of systolic BP. Our findings support PWV as the primary arterial stiffness metric for outcome prediction.
登录
查看更多内容
DOI：
10.1109/tbme.2016.2612639
发表时间：
2017-07
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Gao M;Cheng HM;Sung SH;Chen CH;Olivier NB;Mukkamala R
通讯作者：
Mukkamala R
影响因子：
4.4
作者：
Shirai, Kohji;Song, Mingling;Takahashi, Mao
通讯作者：
Takahashi, Mao
影响因子：
4.4
作者：
Shirai, Kohji;Suzuki, Kenji;Takahashi, Koji
通讯作者：
Takahashi, Koji
影响因子：
2.4
作者：
HAYASHI, K;HANDA, H;MORITAKE, K
通讯作者：
MORITAKE, K
影响因子：
8.3
作者：
Kim, Esther D.;Ballew, Shoshana H.;Matsushita, Kunihiro
通讯作者：
Matsushita, Kunihiro