Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells.
Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells.
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DOI：
10.4049/jimmunol.0900641
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发表时间：
2009-09-01
期刊：
影响因子：
--
通讯作者：
Goldrath AW
中科院分区：
文献类型：
--
作者：
Cheung KP;Yang E;Goldrath AW
幼稚T细胞在淋巴细胞减少时增殖，并获得记忆T细胞的表型和功能特性，提供对感染的增强保护。在淋巴细胞减少诱导内稳态增殖(HP-Memory)过程中产生的记忆样T细胞如何分化为二级记忆细胞并与经历过Ag的真记忆细胞竞争尚不清楚。我们发现，CD8+HP记忆T细胞在感染后产生了强大的反应，并在没有竞争的情况下产生了与真实记忆细胞相当的二级记忆群体。然而，当真记忆T细胞和HP记忆T细胞在感染期间竞争时，HP记忆细胞对效应者群体的贡献较小，收缩较早，形成的次级记忆细胞较少。此外，幽门螺杆菌和真记忆细胞在感染期间表现出明显的趋化因子受体表达和在脾内的定位，表明不同的途径获得二次记忆形成所需的信号。因此，HP记忆T细胞在不影响真实记忆群体的情况下提供保护。HP记忆T细胞和真记忆T细胞的差异可能揭示了记忆T细胞内争夺有限资源的基础。
Naive T cells proliferate in response to lymphopenia and acquire the phenotypic and functional qualities of memory T cells, providing enhanced protection against infection. How well memory-like T cells generated during lymphopenia-induced homeostatic proliferation (HP)-memory differentiate into secondary memory cells and compete with Ag-experienced true-memory cells is unknown. We found that CD8+ HP-memory T cells generated robust responses upon infection and produced a secondary memory population comparable to true-memory cells in the absence of competition. However, when true-memory and HP-memory T cells competed during infection, HP-memory cells contributed less to the effector population, contracted earlier, and formed fewer secondary memory cells. Furthermore, HP- and true-memory cells demonstrated distinct chemokine receptor expression and localization within the spleen during infection, indicating differential access to signals necessary for secondary memory formation. Thus, HP-memory T cells provide protection without compromising the true-memory population. Differences in HP- and true-memory T cells may reveal the basis of competition for limited resources within the memory-T cell compartment.
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影响因子：
4.4
作者：
Prlic, M;Blazar, BR;Jameson, SC
通讯作者：
Jameson, SC
影响因子：
32.4
作者：
Aoshi, Taiki;Zinselmeyer, Bernd H.;Miller, Mark J.
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Miller, Mark J.
影响因子：
20.3
作者：
Craddock, CF;Nakamoto, B;Papayannopoulou, T
通讯作者：
Papayannopoulou, T
DOI：
10.1073/pnas.0600240103
发表时间：
2006-06-13
影响因子：
11.1
作者：
Rubinstein, Mark P.;Kovar, Marek;Sprent, Jonathan
通讯作者：
Sprent, Jonathan
DOI：
10.1084/jem.192.4.549
发表时间：
2000-08-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Chen J