Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions.
Structure-activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions.
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DOI：
10.1016/j.resp.2011.10.015
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发表时间：
2012-01-15
影响因子：
2.3
通讯作者：
Mantilla, Carlos B.
中科院分区：
文献类型：
--
作者：
Sieck, Dylan C.;Zhan, Wen-Zhi;Fang, Yun-Hua;Ermilov, Leonid G.;Sieck, Gary C.;Mantilla, Carlos B.
膈肌（DIAm）是一种高度活跃的混合纤维型肌肉。我们假设，与更大的激活历史和抗疲劳纤维的比例相一致，神经肌肉传递失败在小鼠中低于大鼠DIAm，并且神经肌肉接头（NMJ）形态将匹配其不同的功能需求。小鼠的分钟通气量和占空比高于大鼠。抗疲劳纤维的比例在大鼠和小鼠中相似;然而，抗疲劳纤维对总DIAm质量的贡献在小鼠中更高。小鼠的神经肌肉传递失败比大鼠少。运动终板面积不同的纤维在大鼠，但不是在小鼠DIAm，NMJ显示更大的复杂性整体。因此，不同物种的激活历史和神经肌肉传递失败的易感性的差异反映在抗疲劳肌纤维的总DIAm质量的相对贡献，但不是在NMJ的类型依赖性形态差异。
The diaphragm muscle (DIAm) is a highly active muscle of mixed fiber type composition. We hypothesized that consistent with greater activation history and proportion of fatigue-resistant fibers, neuromuscular transmission failure is lower in the mouse compared to the rat DIAm, and that neuromuscular junction (NMJ) morphology will match their different functional demands. Minute ventilation and duty cycle were higher in the mouse than in the rat. The proportion of fatigue-resistant fibers was similar in the rat and mouse; however the contribution of fatigue-resistant fibers to total DIAm mass was higher in the mouse. Neuromuscular transmission failure was less in mice than in rats. Motor end-plate area differed across fibers in rat but not in mouse DIAm, where NMJs displayed greater complexity overall. Thus, differences across species in activation history and susceptibility to neuromuscular transmission failure are reflected in the relative contribution of fatigue resistant muscle fibers to total DIAm mass, but not in type-dependent morphological differences at the NMJ.
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影响因子：
2.3
作者：
Mantilla, Carlos B.;Seven, Yasin B.;Zhan, Wen-Zhi;Sieck, Gary C.
通讯作者：
Sieck, Gary C.
影响因子：
2.3
作者：
Mantilla, Carlos B.;Seven, Yasin B.;Hurtado-Palomino, Juan N.;Zhan, Wen-Zhi;Sieck, Gary C.
通讯作者：
Sieck, Gary C.
影响因子：
2.3
作者：
Lee KZ;Fuller DD
通讯作者：
Fuller DD
DOI：
10.1164/rccm.200502-262oc
发表时间：
2005-07-15
影响因子：
24.7
作者：
Ottenheijm, CAC;Heunks, LMA;Dekhuijzen, PNR
通讯作者：
Dekhuijzen, PNR
影响因子：
3.3
作者：
LEWIS, MI;SIECK, GC;BELMAN, MJ
通讯作者：
BELMAN, MJ