Digitoxin medication and cancer; case control and internal dose-response studies.
Digitoxin medication and cancer; case control and internal dose-response studies.
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DOI：
10.1186/1471-2407-1-11
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发表时间：
2001
期刊：
影响因子：
3.8
通讯作者：
Tretli S
中科院分区：
文献类型：
--
作者：
Haux J;Klepp O;Spigset O;Tretli S
洋地黄毒苷体外诱导不同人类恶性肿瘤细胞系凋亡。在本文中，我们调查了服用洋地黄毒苷治疗心脏病的患者与普通人群相比是否有不同的癌症发病率。计算机存储的9271例心脏病患者血浆中洋地黄毒苷浓度数据用于定义用户人群。来自挪威癌症登记处的年龄和性别匹配的对照用于计算预期癌症病例的数量。与对照人群相比，服用洋地黄毒苷的人群显示出更高的癌症发病率。然而，一项额外的分析表明，在开始服用洋地黄毒苷之前，服用洋地黄毒苷的人群患癌症的风险已经普遍增加。白血病/淋巴瘤是在开始洋地黄毒苷治疗前洋地黄毒苷人群中风险最高的癌症类型。这表明心血管疾病和淋巴增生性癌症存在未知的风险因素。一项内部剂量反应分析显示，洋地黄毒苷的高血浆浓度与白血病/淋巴瘤和肾癌/尿路癌的风险降低之间存在关系。由于高年龄和心脏病，服用洋地黄毒苷的人群发病率和死亡率很高，这些因素干扰了在这种情况下分离洋地黄毒苷最终抗癌作用的努力。尽管如此，研究结果可能表明洋地黄毒甙对白血病/淋巴瘤和肾脏/泌尿道癌症有抗癌作用。前瞻性临床癌症试验必须做，以找出洋地黄毒苷和其他强心苷是有用的抗癌剂。
Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Computer stored data on digitoxin concentrations in plasma from 9271 patients with cardiac disease were used to define a user population. Age and sex matched controls from the Norwegian Cancer Registry were used to calculate the number of expected cancer cases. The population on digitoxin showed a higher incidence of cancer compared to the control population. However, an additional analysis showed that the population on digitoxin had a general increased risk of cancer already, before the start on digitoxin. Leukemia/lymphoma were the cancer types which stood out with the highest risk in the digitoxin population before starting on digitoxin. This indicates that yet unknown risk factors exist for cardiovascular disease and lymphoproliferative cancer. An internal dose-response analysis revealed a relationship between high plasma concentration of digitoxin and a lower risk for leukemia/lymphoma and for cancer of the kidney/urinary tract. Morbidity and mortality are high in the population on digitoxin, due to high age and cardiac disease.These factors disturb efforts to isolate an eventual anticancer effect of digitoxin in this setting. Still, the results may indicate an anticancer effect of digitoxin for leukemia/lymphoma and kidney/urinary tract cancers. Prospective clinical cancer trials have to be done to find out if digitoxin and other cardiac glycosides are useful as anticancer agents.
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影响因子：
2.3
作者：
Johansson, S;Lindholm, P;Claeson, P
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