Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.
Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.
复制标题
DOI：
10.1093/clinchem/hvaa304
复制
发表时间：
2021-01-30
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
--
作者：
最初研究作为一种机制，以了解妊娠期间子痫相关的死亡，母体血液中的胎儿细胞最近获得了关注，作为产前检测胎儿材料的非侵入性来源。然而，在21世纪世纪，完整的胎儿细胞在很大程度上被循环的无细胞胎盘DNA所取代，用于非整倍体筛查。相反，人们的兴趣已经转向胎儿细胞影响母体生物学的方式。与此同时，越来越多的人认识到母体细胞对发育中的胎儿的影响。在这篇综述中，我们强调了孕妇和胎儿之间的完整细胞的双向贩运的潜在临床应用和功能后果。胎儿细胞在母体疾病的发病机制和组织修复中发挥着潜在的作用。母体细胞在培养胎儿免疫系统方面起着至关重要的作用，也是移植接受的一个因素。自然发生的母体微嵌合体也正在探索作为造血干细胞的来源，用于移植在胎儿造血疾病。未来的人类研究需要包括完整的妊娠史，以了解孕产妇健康和移植成功或失败。动物模型对于理解与母体损伤和炎症相关的胎儿伤口愈合和/或修复的机制是有用的。母亲和孩子之间细胞交换的终身后果是深远的，在发育，健康和疾病方面有许多应用。这种复杂的遗传异质细胞交换创造了一种永久的联系，有助于两个人的生存。
Originally studied as a mechanism to understand eclampsia-related deaths during pregnancy, fetal cells in maternal blood have more recently garnered attention as a noninvasive source of fetal material for prenatal testing. In the 21st century, however, intact fetal cells have been largely supplanted by circulating cell-free placental DNA for aneuploidy screening. Instead, interest has pivoted to the ways in which fetal cells influence maternal biology. In parallel, an increasing appreciation of the consequences of maternal cells in the developing fetus has occurred. In this review, we highlight the potential clinical applications and functional consequences of the bidirectional trafficking of intact cells between a pregnant woman and her fetus. Fetal cells play a potential role in the pathogenesis of maternal disease and tissue repair. Maternal cells play an essential role in educating the fetal immune system and as a factor in transplant acceptance. Naturally occurring maternal microchimerism is also being explored as a source of hematopoietic stem cells for transplant in fetal hematopoietic disorders. Future investigations in humans need to include complete pregnancy histories to understand maternal health and transplant success or failure. Animal models are useful to understand the mechanisms underlying fetal wound healing and/or repair associated with maternal injury and inflammation. The lifelong consequences of the exchange of cells between a mother and her child are profound and have many applications in development, health, and disease. This intricate exchange of genetically foreign cells creates a permanent connection that contributes to the survival of both individuals.
登录
查看更多内容
DOI：
10.1146/annurev-pathmechdis-012418-012743
发表时间：
2019-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Deshmukh H;Way SS
通讯作者：
Way SS
影响因子：
17.1
作者：
Frascoli M;Coniglio L;Witt R;Jeanty C;Fleck-Derderian S;Myers DE;Lee TH;Keating S;Busch MP;Norris PJ;Tang Q;Cruz G;Barcellos LF;Gomez-Lopez N;Romero R;MacKenzie TC
通讯作者：
MacKenzie TC
影响因子：
9.8
作者：
Bianchi, DW;Farina, A;Klinger, KW
通讯作者：
Klinger, KW
影响因子：
0.7
作者：
Gammill, Hilary S.;Nelson, J. Lee
通讯作者：
Nelson, J. Lee
影响因子：
2.4
作者：
Hayashida, Makoto;Nishimoto, Yuko;Taguchi, Tomoaki
通讯作者：
Taguchi, Tomoaki