Aortic stiffness and calcification in men in a population-based international study.
Aortic stiffness and calcification in men in a population-based international study.
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DOI：
10.1016/j.atherosclerosis.2012.03.027
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发表时间：
2012-06
期刊：
影响因子：
5.3
通讯作者：
Sutton-Tyrrell, Kim
中科院分区：
文献类型：
--
作者：
Sekikawa, Akira;Shin, Chol;Curb, J. David;Barinas-Mitchell, Emma;Masaki, Kamal;El-Saed, Aiman;Seto, Todd B.;Mackey, Rachel H.;Choo, Jina;Fujiyoshi, Akira;Miura, Katsuyuki;Edmundowicz, Daniel;Kuller, Lewis H.;Ueshima, Hirotsugu;Sutton-Tyrrell, Kim
主动脉僵硬是血管老化的标志，是心血管疾病和全因死亡率的独立危险因素。尽管在终末期肾病患者或老年受试者中的研究表明主动脉钙化是主动脉僵硬的重要决定因素，但中年普通人群中主动脉僵硬与主动脉钙化的相关性仍未知。本研究的目的是在相对年轻的多种族人群样本中检查主动脉钙化和僵硬的相关性。我们研究了906名40-49岁的男性（81名黑人美国人，276名日裔美国人，258名白色美国人和291名韩国人）。使用自动波形分析仪测量主动脉僵硬度作为颈动脉-股动脉脉搏波速度（cfPWV）。使用电子束计算机断层扫描评价从主动脉弓到髂动脉分叉的主动脉钙化。计算主动脉钙评分，并分为4组：0（n=303）、1-100（n=411）、101-300（n=110）和401+（n=82）。在调整年龄、种族和平均动脉压后，主动脉钙化类别与cfPWV显著正相关（cfPWV（cm/秒）的平均值（标准误）从最低到最高类别：836（10），850（9），877（17）和941（19），趋势p <0.001）。在进一步调整其他心血管危险因素后，显着的正相关仍然存在。在每个种族组中也观察到显着的正相关。结果表明，主动脉钙化可能是主动脉僵硬的一种机制，主动脉钙化与僵硬的关联早在40年代就开始了。
Aortic stiffness, a hallmark of vascular aging, is an independent risk factor of cardiovascular disease and all-cause mortality. The association of aortic stiffness with aortic calcification in middle-aged general population remains unknown although studies in patients with end-stage renal disease or elderly subjects suggest that aortic calcification is an important determinant of aortic stiffness. The goal of this study was to examine the association of aortic calcification and stiffness in multi-ethnic population-based samples of relatively young men. We examined the association in 906 men aged 40–49 (81 Black Americans, 276 Japanese Americans, 258 White Americans and 291 Koreans). Aortic stiffness was measured as carotid-femoral pulse wave velocity (cfPWV) using an automated waveform analyzer. Aortic calcification from aortic arch to iliac bifurcation was evaluated using electron-beam computed tomography. Aortic calcium score was calculated and was categorized into four groups: zero (n=303), 1–100 (n=411), 101–300 (n=110), and 401+ (n=82). Aortic calcification category had a significant positive association with cfPWV after adjusting for age, race, and mean arterial pressure (mean (standard error) of cfPWV (cm/second) from the lowest to highest categories: 836 (10), 850 (9), 877 (17) and 941 (19), p for trend <0.001). The significant positive association remained after further adjusting for other cardiovascular risk factors. The significant positive association was also observed in each race group. The results suggest that aortic calcification can be one mechanism for aortic stiffness and that the association of aortic calcification with stiffness starts as early as the 40’s.
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DOI：
10.1161/atvbaha.110.208181
发表时间：
2010-11-01
影响因子：
8.7
作者：
Criqui, Michael H.;Kamineni, Aruna;Wong, Nathan D.
通讯作者：
Wong, Nathan D.
影响因子：
4.9
作者：
Tanaka, Hirofumi;Munakata, Masanori;Ozawa, Toshio
通讯作者：
Ozawa, Toshio
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
影响因子：
37.8
作者：
Post, Wendy;Bielak, Lawrence F.;Mitchell, Braxton D.
通讯作者：
Mitchell, Braxton D.
影响因子：
8.3
作者：
Niederhoffer, N;LartaudIdjouadiene, I;Atkinson, J
通讯作者：
Atkinson, J