Association Between High-Sensitivity C-Reactive Protein and Diabetic Kidney Disease in Patients With Type 2 Diabetes Mellitus.
Association Between High-Sensitivity C-Reactive Protein and Diabetic Kidney Disease in Patients With Type 2 Diabetes Mellitus.
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2 型糖尿病患者高敏 C 反应蛋白与糖尿病肾病之间的关联
DOI：
10.3389/fendo.2022.885516
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发表时间：
2022
影响因子：
5.2
通讯作者：
Peng, Yong-De
中科院分区：
文献类型：
--
作者：
Tang, Min;Cao, Han;Wei, Xiao-Hui;Zhen, Qin;Liu, Fang;Wang, Yu-Fan;Fan, Neng-Guang;Peng, Yong-De
关键词：
目的超敏C反应蛋白（hs-CRP）是一种炎症标志物。本研究旨在探讨2型糖尿病（T2 DM）患者血清超敏C反应蛋白（hs-CRP）水平与糖尿病肾病（DKD）的相关性。材料/方法本横断面观察性研究纳入927例2型糖尿病患者。我们根据患者的医疗数据收集数据，包括社会人口学特征、伴随疾病、实验室检查结果和药物治疗。多因素Logistic回归分析hs-CRP水平与DKD的关系。使用限制三次样条（RCS）来评估连续尺度上hs-CRP水平与DKD的相关性。结果共纳入927例患者。招募患者的中位年龄为55岁，其中女性患者346例，男性患者581例。DKD患者血清hs-CRP水平明显高于非DKD患者。在调整年龄、性别、舒张压、收缩压、体重指数、颈围、腰围、高血压、糖尿病病程、颈总动脉斑块、空腹血糖、糖化血红蛋白、血红蛋白、红细胞、白细胞、γ-谷氨酰转移酶、白蛋白、尿素氮、尿酸和甘油三酯后，与第一个四分位数相比，第四个四分位数中DKD的比值比（OR）显著增加（趋势P值= 0.003），DKD与第一四分位数相比，hs-CRP第四分位数的OR（95%置信区间）为1.968（1.244-3.114）。此外，RCS曲线显示hs-CRP与DKD之间分别在全体受试者、男性受试者和女性受试者中呈正相关。结论血清hs-CRP水平与DKD的发生呈正相关，对DKD的诊断和预测有一定的临床应用价值。
Objective High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker. This study aimed to identify the correlation between hs-CRP levels and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Materials/Methods This cross-sectional and observational study included 927 patients with T2DM. We collected the data of patients based on their medical data, including sociodemographic characteristics, concomitant diseases, laboratory results, and medical therapy. Multivariate logistic regression analysis was conducted to assess the relationship between hs-CRP levels and DKD. A restricted cubic spline (RCS) was used to assess the correlation of hs-CRP levels on a continuous scale with the DKD. Results In total, 927 patients were recruited in our study. The median age of the recruited patients was 55 years, and there were 346 female patients and 581 male patients. The hs-CRP levels were evidently higher in patients with DKD than those without DKD. After adjusting for age, sex, diastolic blood pressure, systolic blood pressure, body mass index, neck circumference, waist circumference, hypertension, duration of diabetes, common carotid artery plaque, fasting plasma glucose, glycated hemoglobin, hemoglobin, erythrocyte, leukocyte, γ-glutamyl transferase, albumin, urea nitrogen, uric acid and triglyceride, a significant increase in the odds ratios (ORs) for DKD in the fourth hs-CRP quartile compared with the first quartile was observed (P value for trend= 0.003), and the ORs (95% confidence intervals) in the fourth quartile of hs-CRP were 1.968 (1.244–3.114) for DKD compared to the first quartile.. Moreover, the RCS curves presented a positive association between hs-CRP and DKD in total subjects, male subjects and female subjects, respectively. Conclusions The results of our study indicated that hs-CRP levels were significantly and positively correlated with the presence of DKD, which may provide predictive and diagnostic values in clinical practice.
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影响因子：
16.2
作者：
Sinha SK;Shaheen M;Rajavashisth TB;Pan D;Norris KC;Nicholas SB
通讯作者：
Nicholas SB
影响因子：
4.2
作者：
Garcia-Garcia, Patricia M.;Getino-Melian, Maria A.;Navarro-Gonzalez, Juan F.
通讯作者：
Navarro-Gonzalez, Juan F.
影响因子：
9.8
作者：
Moriwaki, Y;Yamamoto, T;Hada, T
通讯作者：
Hada, T
影响因子：
4.2
作者：
Navarro, Juan F.;Milena, Francisco J.;Garcia, Javier
通讯作者：
Garcia, Javier
影响因子：
3
作者：
Jenkins, Alicia J.;Rothen, Michelle;Lyons, Timothy J.
通讯作者：
Lyons, Timothy J.