Sodium-lithium countertransport activity in normotensive offspring of hypertensive black Africans
Sodium-lithium countertransport activity in normotensive offspring of hypertensive black Africans
复制标题
高血压黑人非洲人血压正常的后代的钠-锂反转运活动
DOI：
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复制
发表时间：
1998
影响因子：
2.7
通讯作者：
I. Oforofuo
中科院分区：
文献类型：
--
作者：
A. Obasohan;C. Osuji;I. Oforofuo
目的：评估黑人（尼日利亚）高血压（HT）患者、高血压父母的正常血压（NT）后代和正常血压父母的正常血压后代的钠锂反转运（SLC）活性和红细胞钠（ENa）水平，并确定SLC活性升高是否与黑人（高加索人）高血压家族性易感性有关。方法：将60名尼日利亚江户裔受试者分为三组，每组20人：(a)贝宁市大学教学医院未经治疗的新发HT患者；(b)父母有高血压的NT儿童（NTHT）与父母有高血压的NT儿童（NTNT）在年龄、性别和身体质量指数（BMI）方面进行家访匹配。SLC活性采用Canessa等人1980年改进的方法测定，ENa采用火焰光度法测定。结果：HT患者和NTHT患者的SLC均明显高于nnt患者。分别为0.351±0.011 vs 0.199±0.014 mmol Li/rbc （P < 0.0001）和0.347±0.020 vs 0.199±0.014 mmol Li/rbc/hr （P < 0.0001）。两组间差异无统计学意义（P < 0.05）。HT组的ENa高于NT组，两者相似。值分别为10.55±0.46 (HT)和7.78±0.62 (NTHT) (P < 0.0001)和10.55±0.46 vs 8.62±0.47 (HT)更易与L (P < 0.0001)。SLC活性或ena与任何其他测量变量（如年龄或bmt）之间没有相关性。结论：高血压患者的正常儿童的SLC活性升高程度与高血压患者相似，其模式与白种人相似。因此，SLC活性可能与黑人和白种人的高血压家族易感性有关。
Objective: To assess sodium-lithium countertransport (SLC) activity and erythrocyte sodium (ENa) levels in black (Nigerian) hypertensive (HT) patients, normotensive (NT) offspring of hypertensive parents and normotensive offspring of normotensive parents, and to determine if increased SLC activity is related to a familial predisposition to hypertension in black subjects as in Caucasians. Method: The study was done using 60 Nigerian subjects of Edo ethnic origin in three groups of 20 each: (a) untreated new HT patients at the University Teaching Hospital, Benin City; (b) NT children of hypertensive parents (NTHT) traced home and matched for age, sex and body mass index (BMI) with (c) NT children of NT parents (NTNT). SLC activity was measured using a modified method of Canessa et al 1980 and ENa assessed by flame photometry. Results: SLC was markedly higher in both HT patients and NTHT subjects than the NTNT subjects. The values were 0.351 ± 0.011 vs 0.199 ± 0.014 mmol Li/rbc (P < 0.0001) and 0.347 ± 0.020 vs 0.199 ± 0.014 mmol Li/rbc/hr (P < 0.0001), respectively. the values were not different between the ht and the ntht group (P > 0.05). ENa was higher in the HT group than both NT groups which were similar. Values were 10.55 ± 0.46 (HT) vs 7.78 ± 0.62 (NTHT) (P < 0.0001) and 10.55 ± 0.46 (ht) vs 8.62 ± 0.47 mmol/L (P < 0.0001). there were no correlations between either slc activity or ena and any of the other measured variables such as age or bmt. Conclusions: SLC activity was elevated in normotensive children of hypertensive subjects to a similar degree as hypertensive patients and in a pattern reminiscent of that seen in Caucasians. SLC activity may thus be associated with a familial predisposition to hypertension in black subjects as in their Caucasian counterparts.
离子调节的种族差异及其与黑人高血压的可能联系。
DOI：
10.1161/01.hyp.14.6.584
发表时间：
1989
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Aviv,A;Gardner,J
通讯作者：
Gardner,J
钠-锂逆向转运基因型和成人高血压的概率。
DOI：
10.1161/01.hyp.22.4.560
发表时间：
1993
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Rebbeck,TR;Turner,ST;Sing,CF
通讯作者：
Sing,CF
tecumseh 血压研究中的红细胞锂钠反转运。
DOI：
10.1161/01.hyp.17.5.652
发表时间：
1991
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Weder,AB;Schork,NJ;Krause,L;Julius,S
通讯作者：
Julius,S