Functional imaging of implicit marijuana associations during performance on an Implicit Association Test (IAT).
Functional imaging of implicit marijuana associations during performance on an Implicit Association Test (IAT).
复制标题
DOI：
10.1016/j.bbr.2013.09.013
复制
发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Bechara, Antoine
中科院分区：
文献类型：
--
作者：
Ames, Susan L.;Grenard, Jerry L.;Stacy, Alan W.;Xiao, Lin;He, Qinghua;Wong, Savio W.;Xue, Gui;Wiers, Reinout W.;Bechara, Antoine
这项研究通过大麻内隐联想测试的成像(FMRI)来评估内隐联想记忆过程(基于习惯的过程)的神经相关性。与药物相关的联想记忆效应已被证明可以一致地预测药物使用的水平。为了观察联想记忆效应的神经活动的差异，本研究比较了13名吸食大量大麻的人和15名不使用大麻的对照组，年龄从18岁到25岁不等，进行了大麻内隐联想测试(IAT)。观察到壳核、尾状回和右额下回的相互作用。与非吸毒者相比，吸食大麻的人在关注使用的积极结果的相容试验中，在背侧纹状体(尾状核和壳核)表现出更大的双侧活动。或者，与吸食大麻的那组人相比，在不相容的试验中，没有吸食大麻的人在右额下回表现出更大的活动，这需要更费力地处理信息。此外，相对于注视，重度使用者在相容试验中在尾状核和壳核、海马体和一些额叶区域显示出双侧活动，而在不相容试验中没有明显的活动。非使用组在不相容试验中与固定相关的额部区域表现出更大的活动，而在相容试验中没有显着的活动。这些发现与食欲行为的双重加工框架一致，该框架提出：(1)潜在习惯的内隐联系是通过纹状体依赖的神经回路调节的，(2)考虑/控制行为是通过更依赖于前额叶皮质的回路调节的。
This research evaluated the neural correlates of implicit associative memory processes (habit-based processes) through the imaging (fMRI) of a marijuana Implicit Association Test. Drug-related associative memory effects have been shown to consistently predict level of drug use. To observe differences in neural activity of associative memory effects, this study compared 13 heavy marijuana users and 15 non-using controls, ranging in age from 18 to 25, during performance of a marijuana Implicit Association Test (IAT). Group by condition interactions in the putamen, caudate, and right inferior frontal gyrus were observed. Relative to non-users, marijuana users showed greater bilateral activity in the dorsal striatum (caudate and putamen) during compatible trials focused on perceived positive outcomes of use. Alternatively, relative to the marijuana-using group, the non-users showed greater activity in the right inferior frontal gyrus during incompatible trials, which require more effortful processing of information. Further, relative to fixation, heavy users showed bilateral activity in the caudate and putamen, hippocampus and some frontal regions during compatible trials and no significant activity during incompatible trials. The non-using group showed greater activity in frontal regions during incompatible trials relative to fixation and no significant activity during compatible trials. These findings are consistent with a dual process framework of appetitive behaviors proposing that (1) implicit associations underlying habit are mediated through neural circuitry dependent on the striatum, and (2) deliberative/controlled behaviors are mediated through circuitry more dependent on the prefrontal cortex.
登录
查看更多内容
影响因子：
5.3
作者：
Corbille, Anne-Gaelle;Valjent, Emmanuel;Girault, Jean-Antoine
通讯作者：
Girault, Jean-Antoine
DOI：
10.1016/j.jbtep.2004.05.001
发表时间：
2004-12-01
影响因子：
1.8
作者：
De Houwer, J;Crombez, G;De Beul, N
通讯作者：
De Beul, N
影响因子：
--
作者：
Everitt, BJ;Dickinson, A;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
2.7
作者：
Ames, SL;Sussman, S;Stacy, AW
通讯作者：
Stacy, AW
影响因子：
5.6
作者：
Chang, Linda;Chronicle, Edward P.
通讯作者：
Chronicle, Edward P.