Long-term radiation-related health effects in a unique human population: lessons learned from the atomic bomb survivors of Hiroshima and Nagasaki.
Long-term radiation-related health effects in a unique human population: lessons learned from the atomic bomb survivors of Hiroshima and Nagasaki.
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DOI：
10.1001/dmp.2011.21
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发表时间：
2011-03
影响因子：
2.7
通讯作者：
Shore, Roy E.
中科院分区：
文献类型：
--
作者：
Douple, Evan B.;Mabuchi, Kiyohiko;Cullings, Harry M.;Preston, Dale L.;Kodama, Kazunori;Shimizu, Yukiko;Fujiwara, Saeko;Shore, Roy E.
63年来，原子弹伤亡委员会及其继任者辐射影响研究基金会的科学家们一直在评估广岛和长崎原子弹爆炸幸存者及其子女的长期健康影响。大量人口的确定和后续行动（总数约为200，000人，其中40%以上至今仍活着），其中包括广泛的年龄和辐射暴露剂量，以及男女健康代表;建立定义明确的队列，其成员已被纵向研究，其中一些成员每两年进行一次健康检查，幸存者参与率很高;对个人辐射剂量的仔细重建，为幸存者和全人类带来了与辐射有关的健康影响，包括对人类的癌症和非癌症影响的可靠的超额相对风险估计。本文回顾了这些风险估计，并总结了从这项历史性的独特研究中学到的东西。
For 63 years scientists in the Atomic Bomb Casualty Commission and its successor, the Radiation Effects Research Foundation, have been assessing the long-term health effects in the survivors of the atomic bombings of Hiroshima and Nagasaki and in their children. The identification and follow-up of a large population (approximately a total of 200 000, of whom more than 40% are alive today) that includes a broad range of ages and radiation exposure doses, and healthy representatives of both sexes; establishment of well-defined cohorts whose members have been studied longitudinally, including some with biennial health examinations and a high survivor participation rate; and careful reconstructions of individual radiation doses have resulted in reliable excess relative risk estimates for radiation-related health effects, including cancer and noncancer effects in humans, for the benefit of the survivors and for all humankind. This article reviews those risk estimates and summarizes what has been learned from this historic and unique study.
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