Human conditions of insulin-like growth factor-I (IGF-I) deficiency.
Human conditions of insulin-like growth factor-I (IGF-I) deficiency.
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DOI：
10.1186/1479-5876-10-224
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发表时间：
2012-11-14
影响因子：
7.4
通讯作者：
Castilla-Cortázar I
中科院分区：
文献类型：
--
作者：
Puche JE;Castilla-Cortázar I
胰岛素样生长因子I（IGF-I）是一种多肽激素，主要由肝脏响应内分泌GH刺激产生，但也由多种组织分泌，用于自分泌/旁分泌目的。IGF-I部分负责全身GH活动，尽管它具有广泛的自身特性（合成代谢，抗氧化，抗炎和细胞保护作用）。IGF-I是一种受密切调节的激素。因此，其合理的治疗应用似乎仅限于恢复生理循环水平，以恢复IGF-I缺乏的临床后果，尽管存在持续的差异，但IGF-I治疗从未与肿瘤发生相关。目前，IGF-I缺乏症的最佳特征是儿童的Laron综合征;成人的肝硬化;衰老，包括与年龄相关的心血管和神经系统疾病;以及最近的宫内生长受限。本综述的目的是总结IGF-I在生理和病理条件下越来越多的作用列表，其潜在的治疗选择似乎仅限于那些已证实的局部或全身IGF-I缺乏症的替代治疗，而不是将其水平提高到正常范围以上。
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions). IGF-I is a closely regulated hormone. Consequently, its logical therapeutical applications seems to be limited to restore physiological circulating levels in order to recover the clinical consequences of IGF-I deficiency, conditions where, despite continuous discrepancies, IGF-I treatment has never been related to oncogenesis. Currently the best characterized conditions of IGF-I deficiency are Laron Syndrome, in children; liver cirrhosis, in adults; aging including age-related-cardiovascular and neurological diseases; and more recently, intrauterine growth restriction. The aim of this review is to summarize the increasing list of roles of IGF-I, both in physiological and pathological conditions, underlying that its potential therapeutical options seem to be limited to those proven states of local or systemic IGF-I deficiency as a replacement treatment, rather than increasing its level upper the normal range.
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影响因子：
64.5
作者：
BAKER, J;LIU, JP;EFSTRATIADIS, A
通讯作者：
EFSTRATIADIS, A
影响因子：
1.4
作者：
Belobrajdic, Damien P.;Priebe, Ilka K.;Saunders, Ian W.
通讯作者：
Saunders, Ian W.
影响因子：
3.4
作者：
Adashi, EY
通讯作者：
Adashi, EY
影响因子：
4.8
作者：
BEHRINGER, RR;LEWIN, TM;DERCOLE, AJ
通讯作者：
DERCOLE, AJ
影响因子：
4.3
作者：
Abdulle, Abdishakur M.;Gillett, Michael P. T.;Singh, Jaipaul
通讯作者：
Singh, Jaipaul