Occupational exposure to chemicals and fetal growth: the Generation R Study.
Occupational exposure to chemicals and fetal growth: the Generation R Study.
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DOI：
10.1093/humrep/der437
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Burdorf A
中科院分区：
文献类型：
--
作者：
Snijder CA;Roeleveld N;Te Velde E;Steegers EA;Raat H;Hofman A;Jaddoe VW;Burdorf A
出生缺陷、生长受限和早产等发育性疾病占婴儿死亡率和发病率的25%以上。一些研究表明，怀孕期间接触化学品与不良的出生结果有关。本研究的目的是确定职业暴露于各种化学品是否可能对宫内生长模式和胎盘重量产生不利影响。在荷兰（2002-2006年），对4680名孕妇进行了一项基于人群的前瞻性队列研究，研究了孕妇职业暴露于各种化学品与胎儿生长之间的关系。在怀孕中期填写调查问卷的母亲（回答：77%的登记），如果他们在怀孕期间进行有偿就业，并有一个自发怀孕的单胎活产妊娠（n = 4680）。使用了一个工作接触矩阵，将职称与专家对工作场所接触化学品的判断联系起来。通过超声反复测量胎儿生长特征，并与出生时的测量结果结合使用。胎盘重量来自医疗记录和医院登记处。重复测量的线性回归模型被用来研究母亲职业暴露于化学品和宫内生长之间的关联。我们观察到，母亲职业暴露于多环芳烃，邻苯二甲酸酯，烷基酚化合物和农药对胎儿生长的几个领域（胎儿体重，胎儿头围和胎儿长度）产生不利影响。我们发现农药和邻苯二甲酸酯暴露与胎盘重量下降之间存在显著关联。我们的研究结果表明，母亲职业暴露于几种化学品与受损的胎儿生长在怀孕期间和胎盘重量下降。需要进一步的研究来证实这些发现，并评估产后后果。
Developmental diseases, such as birth defects, growth restriction and preterm delivery, account for >25% of infant mortality and morbidity. Several studies have shown that exposure to chemicals during pregnancy is associated with adverse birth outcomes. The aim of this study was to identify whether occupational exposure to various chemicals might adversely influence intrauterine growth patterns and placental weight. Associations between maternal occupational exposure to various chemicals and fetal growth were studied in 4680 pregnant women participating in a population-based prospective cohort study from early pregnancy onwards in the Netherlands (2002–2006), the Generation R Study. Mothers who filled out a questionnaire during mid-pregnancy (response: 77% of enrolment) were included if they conducted paid employment during pregnancy and had a spontaneously conceived singleton live born pregnancy (n = 4680). A job exposure matrix was used, linking job titles to expert judgement on exposure to chemicals in the workplace. Fetal growth characteristics were repeatedly measured by ultrasound and were used in combination with measurements at birth. Placental weight was obtained from medical records and hospital registries. Linear regression models for repeated measurements were used to study the associations between maternal occupational exposure to chemicals and intrauterine growth. We observed that maternal occupational exposure to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds and pesticides adversely influenced several domains of fetal growth (fetal weight, fetal head circumference and fetal length). We found a significant association between pesticide and phthalate exposure with a decreased placental weight. Our results suggest that maternal occupational exposure to several chemicals is associated with impaired fetal growth during pregnancy and a decreased placental weight. Further studies are needed to confirm these findings and to assess post-natal consequences.
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影响因子：
--
作者：
Hines, Cynthia J.;Hopf, Nancy B. Nilsen;Sammons, Deborah L.
通讯作者：
Sammons, Deborah L.
影响因子：
7.2
作者：
Coolman, Marianne;de Groot, Christianne J. M.;Steegers, Eric A. P.
通讯作者：
Steegers, Eric A. P.
影响因子：
13.6
作者：
Jaddoe, Vincent W. V.;Mackenbach, Johan P.;Hofman, Albert
通讯作者：
Hofman, Albert
影响因子：
4.9
作者：
Brouwers, M. M.;van Tongeren, M.;Roeleveld, N.
通讯作者：
Roeleveld, N.
DOI：
10.1111/j.1552-6909.2009.01092.x
发表时间：
2010-01-01
影响因子：
1.8
作者：
Gilden, Robyn C.;Huffling, Katie;Sattler, Barbara
通讯作者：
Sattler, Barbara