Histological confirmation of breast cancer registration and self-reporting in England and Wales: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening.
Histological confirmation of breast cancer registration and self-reporting in England and Wales: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening.
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DOI：
10.1038/bjc.2012.155
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发表时间：
2012-06-05
影响因子：
8.8
通讯作者：
Menon, U.
中科院分区：
文献类型：
--
作者：
Fourkala, E. O.;Gentry-Maharaj, A.;Burnell, M.;Ryan, A.;Manchanda, R.;Dawnay, A.;Jacobs, I.;Widschwendter, M.;Menon, U.
在研究中，癌症诊断的准确信息至关重要。在患有乳腺癌（BC）的女性中，我们比较了英格兰/威尔士的癌症登记（CR）和自我报告与独立确认。在英国卵巢癌筛查合作试验中，通过（1）CR（2011年10月17日）和（2）使用事后问卷的自我报告获得随机化至2009年12月31日之间诊断的BC通知。使用由治疗临床医生完成的详细问卷（BC问卷BCQ）（金标准）确认乳腺癌。计算CR/自我报告与BCQ的表观敏感性和阳性预测值。在1065名可能有BC通知的妇女中，932名（87.5%）被确诊。在BCQ中，共有3.1%（28/918）的BC CR和12.4%（128/1032）的自我报告BC的女性仅患有原位癌。另外4.6%（932人中的43人）的BCQ确认的癌症没有BC登记，3.6%（932人中的34人）没有自我报告BC。CR和自我报告与BCQ的表观敏感性分别为95.4%和96.4%。自我报告的阳性预测值（87.1%）显著低于CR（96.8%）。年龄<65岁的女性更可能将原位癌过度报告为BC。总体而言，如果CR，73例（6.8%）女性会被错误分类/遗漏，如果仅使用自我报告数据，则为167例（15.6%）。这项研究证实了英格兰/威尔士BC登记的可靠性，并强调了一个事实，即十分之一的女性自我报告BC可能只患有原位乳腺癌。
In research studies, accurate information of cancer diagnosis is crucial. In women with breast cancer (BC), we compare cancer registration (CR) in England/Wales and self-reporting with independent confirmation. In the UK Collaborative Trial of Ovarian Cancer Screening, notification of BC diagnosed between randomisation and 31 December 2009 was obtained through (1) CR (17 October 2011) and (2) self-reporting using postal-questionnaire. Breast cancer was confirmed using a detailed questionnaire (BC questionnaire BCQ) completed by the treating clinician (gold standard). Apparent sensitivity and positive-predictive value of CR/self-reporting vs BCQ were calculated. Of 1065 women with possible BC notification, diagnosis was confirmed in 932 (87.5%). A total of 3.1% (28 out of 918) of BC CR and 12.4% (128 out of 1032) of women with self-reported BC only had in-situ carcinoma on BCQ. Another 4.6% (43 out of 932) of BCQ-confirmed cancer did not have a BC registration, and 3.6% (34 out of 932) did not self-report BC. Apparent sensitivity of CR and self-reporting vs BCQ were 95.4 and 96.4%, respectively. Positive-predictive value of self-reporting (87.1%) was significantly lower than that of CR (96.8%). Women aged<65 were more likely to over report in-situ carcinoma as BC. Overall, 73 (6.8%) women would have been misclassified/missed if CR, and 167 (15.6%) if self-reporting data alone was used. This study confirms the reliability of BC registration in England/Wales and highlights the fact that 1 in 10 women self-reporting BC might only have in-situ breast carcinoma.
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影响因子：
8.8
作者：
Moller, H.;Richards, S.;Hanchett, N.;Riaz, S. P.;Luechtenborg, M.;Holmberg, L.;Robinson, D.
通讯作者：
Robinson, D.
影响因子：
3.8
作者：
Abraham, Linn;Geller, Berta M.;Yankaskas, Bonnie C.;Bowles, Erin J. A.;Karliner, Leah S.;Taplin, Stephen H.;Miglioretti, Diana L.
通讯作者：
Miglioretti, Diana L.
DOI：
10.1186/bcr1352
发表时间：
2005
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Gathani T;Bull D;Green J;Reeves G;Beral V;Million Women Study Collaborators
通讯作者：
Million Women Study Collaborators
影响因子：
5
作者：
Desai, MM;Bruce, ML;Druss, BG
通讯作者：
Druss, BG
影响因子：
45.3
作者：
Phillips, KA;Milne, RL;Hopper, JL
通讯作者：
Hopper, JL