Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota.
Impact of Maternal Intrapartum Antibiotics, and Caesarean Section with and without Labour on Bifidobacterium and Other Infant Gut Microbiota.
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DOI：
10.3390/microorganisms9091847
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发表时间：
2021-08-31
期刊：
影响因子：
4.5
通讯作者：
Kozyrskyj AL
中科院分区：
文献类型：
--
作者：
Chen YY;Zhao X;Moeder W;Tun HM;Simons E;Mandhane PJ;Moraes TJ;Turvey SE;Subbarao P;Scott JA;Kozyrskyj AL
背景与目的：很少有研究考虑与出生、分娩方式、产时预防使用抗生素和分娩开始有关的多种因素对双歧杆菌丰度和双歧杆菌属及其种长双歧杆菌亚种数量的共同影响。婴儿肠道菌群中的婴儿。我们实施了这样一项研究。方法：对1654名加拿大足月婴儿在3个月时收集的粪便样本进行肠道微生物群的16S rRNA测序；双歧杆菌属和长双歧杆菌亚种。采用qPCR对婴儿进行定量。双歧杆菌和其他肠道微生物群之间的关联通过Spearman秩相关进行了检验。结果：阴道分娩后，母体IAP暴露与阴道分娩婴儿中双歧杆菌绝对数量减少有关（6.80对7.14 log10（基因拷贝/g粪便），p < 0.05），以及它们相对于其他肠道微生物群的丰度降低。婴儿肠道双歧杆菌数量的IAP差异与母亲孕前体重指数（BMI）无关，值得注意的是，它们仅限于母乳喂养的婴儿。孕前BMI调整显示，双歧杆菌绝对数量与非母乳喂养婴儿伴产或不产的CS，以及纯母乳喂养婴儿伴产的CS之间存在负相关。双歧杆菌丰度与其他微生物类群呈显著相关。结论：本研究记录了出生方式和喂养状态对肠道双歧杆菌丰度的影响，并指出双歧杆菌属在婴儿早期与其他肠道微生物群有很强的相互作用，在肠道微生物群中具有重要的生态作用。
Background and Aims: Few studies consider the joint effect of multiple factors related to birth, delivery mode, intrapartum antibiotic prophylaxis and the onset of labour, on the abundance of Bifidobacterium and the quantity of this genus and its species Bifidobacterium longum subsp. infantis in the infant gut microbiota. We implemented such a study. Methods: Among 1654 Canadian full-term infants, the gut microbiota of faecal samples collected at 3 months were profiled by 16S rRNA sequencing; the genus Bifidobacterium and Bifidobacterium longum subsp. infantis were quantified by qPCR. Associations between Bifidobacterium and other gut microbiota were examined by Spearman’s rank correlation. Results: Following vaginal birth, maternal IAP exposure was associated with reduced absolute quantities of bifidobacteria among vaginally delivered infants (6.80 vs. 7.14 log10 (gene-copies/g faeces), p < 0.05), as well as their lowered abundance relative to other gut microbiota. IAP differences in infant gut bifidobacterial quantity were independent of maternal pre-pregnancy body-mass-index (BMI), and remarkably, they were limited to breastfed infants. Pre-pregnancy BMI adjustment revealed negative associations between absolute quantities of bifidobacteria and CS with or without labour in non-breastfed infants, and CS with labour in exclusively breastfed infants. Significant correlations between Bifidobacterium abundance and other microbial taxa were observed. Conclusions: This study documented the impact of the birth mode and feeding status on the abundance of gut Bifidobacterium, and pointed to the important ecological role of the genus Bifidobacterium in gut microbiota due to its strong interaction with other gut microbiota in early infancy.
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影响因子：
4.4
作者：
Alcon-Giner C;Caim S;Mitra S;Ketskemety J;Wegmann U;Wain J;Belteki G;Clarke P;Hall LJ
通讯作者：
Hall LJ
影响因子：
5.9
作者：
Cortés-Macías E;Selma-Royo M;Martínez-Costa C;Collado MC
通讯作者：
Collado MC
影响因子：
12.2
作者：
Grech A;Collins CE;Holmes A;Lal R;Duncanson K;Taylor R;Gordon A
通讯作者：
Gordon A
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y