Breastfeeding Practices Influence the Breast Milk Microbiota Depending on Pre-Gestational Maternal BMI and Weight Gain over Pregnancy.
Breastfeeding Practices Influence the Breast Milk Microbiota Depending on Pre-Gestational Maternal BMI and Weight Gain over Pregnancy.
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DOI：
10.3390/nu13051518
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发表时间：
2021-04-30
期刊：
影响因子：
5.9
通讯作者：
Collado MC
中科院分区：
文献类型：
--
作者：
Cortés-Macías E;Selma-Royo M;Martínez-Costa C;Collado MC
母乳喂养对于新生儿微生物和免疫系统的充分发育至关重要，影响新生儿短期和长期的健康结果。人们对确定哪些是对乳汁微生物群有贡献的母体因素以及与发育中的婴儿的潜在相关性非常感兴趣。因此，我们的研究旨在描述混合和纯母乳喂养实践对牛奶微生物群的影响，并确定孕前体重指数（BMI）和怀孕期间体重增加对其组成的影响。在产后第一个月内收集了136名健康女性的母乳样本，并通过16S rRNA基因测序分析了乳汁微生物群。记录母乳喂养习惯和母婴临床资料。母乳喂养实践（纯母乳喂养与混合母乳喂养）、母亲孕前BMI和孕期体重增加导致了母乳微生物群的变化。具有纯母乳喂养习惯的孕前体重正常的女性与其他女性相比，双歧杆菌属的丰度显着更高，α多样性也更高。我们的研究结果证实了在怀孕期间控制体重和母乳喂养对牛奶微生物群的重要性。有必要进一步研究，以澄清这些母体因素对牛奶和婴儿发育和健康的潜在影响。
Breastfeeding is critical for adequate neonatal microbial and immune system development affecting neonate health outcomes in the short and long term. There is a great interest in ascertaining which are the maternal factors contributing to the milk microbiota and the potential relevance for the developing infant. Thus, our study aimed to characterize the effect of mixed and exclusive breastfeeding practices on the milk microbiota and to determine the impact of pre-pregnancy body mass index (BMI) and weight gain over pregnancy on its composition. Breast milk samples from 136 healthy women were collected within the first month post-partum and milk microbiota profiling was analyzed by 16S rRNA gene sequencing. Information on breastfeeding habits and maternal-infant clinical data were recorded. Breastfeeding practices (exclusive vs. mixed), maternal pre-gestational BMI, and weight gain over pregnancy contributed to the milk microbiota variation. Pre-gestational normal-weight women with exclusive breastfeeding habits harbored a significantly higher abundance of Bifidobacterium genus, and also, higher alpha-diversity compared to the rest of the women. Our results confirm the importance of controlling weight during pregnancy and breastfeeding practices in terms of milk microbiota. Further studies to clarify the potential impact of these maternal factors on milk and infant development and health will be necessary.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
12.2
作者：
García-Mantrana I;Selma-Royo M;González S;Parra-Llorca A;Martínez-Costa C;Collado MC
通讯作者：
Collado MC
影响因子：
4.4
作者：
Cruaud, Perrine;Vigneron, Adrien;Cambon-Bonavita, Marie-Anne
通讯作者：
Cambon-Bonavita, Marie-Anne
影响因子：
11
作者：
Dzidic, Majda;Collado, Maria C.;Mira, Alex
通讯作者：
Mira, Alex
影响因子：
5
作者：
Hermansson, Henriina;Kumar, Himanshu;Rautava, Samuli
通讯作者：
Rautava, Samuli